Effects of arterial load variations on dynamic arterial elastance: an experimental study

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dc.contributor.authorMonge Garcia, M. I.
dc.contributor.authorGuijo Gonzalez, P.
dc.contributor.authorGracia Romero, M.
dc.contributor.authorGil Cano, A.
dc.contributor.authorRhodes, A.
dc.contributor.authorGrounds, R. M.
dc.contributor.authorCecconi, M.
dc.contributor.authoraffiliation[Monge Garcia, M. I.] St Georges Healthcare NHS Trust & St Georges Univ, Dept Intens Care Med, London SW17 0QT, England
dc.contributor.authoraffiliation[Rhodes, A.] St Georges Healthcare NHS Trust & St Georges Univ, Dept Intens Care Med, London SW17 0QT, England
dc.contributor.authoraffiliation[Grounds, R. M.] St Georges Healthcare NHS Trust & St Georges Univ, Dept Intens Care Med, London SW17 0QT, England
dc.contributor.authoraffiliation[Cecconi, M.] St Georges Healthcare NHS Trust & St Georges Univ, Dept Intens Care Med, London SW17 0QT, England
dc.contributor.authoraffiliation[Monge Garcia, M. I.] Hosp SAS Jerez, Serv Cuidados Intens, C Circunvalaci S-N, Jerez de la Frontera 11407, Spain
dc.contributor.authoraffiliation[Guijo Gonzalez, P.] Hosp SAS Jerez, Serv Cuidados Intens, C Circunvalaci S-N, Jerez de la Frontera 11407, Spain
dc.contributor.authoraffiliation[Gracia Romero, M.] Hosp SAS Jerez, Serv Cuidados Intens, C Circunvalaci S-N, Jerez de la Frontera 11407, Spain
dc.contributor.authoraffiliation[Gil Cano, A.] Hosp SAS Jerez, Serv Cuidados Intens, C Circunvalaci S-N, Jerez de la Frontera 11407, Spain
dc.contributor.funderSt George's University of London, UK
dc.date.accessioned2025-01-07T12:54:29Z
dc.date.available2025-01-07T12:54:29Z
dc.date.issued2017-06-01
dc.description.abstractBackground. Dynamic arterial elastance (Ea(dyn)), the relationship between pulse pressure variation (PPV) and stroke volume variation (SVV), has been suggested as a functional assessment of arterial load. The aim of this study was to evaluate the impact of arterial load changes during acute pharmacological changes, fluid administration, and haemorrhage on Eadyn.Methods. Eighteen anaesthetized, mechanically ventilated New Zealand rabbits were studied. Arterial load changes were induced by phenylephrine (n=9) or nitroprusside (n=9). Thereafter, animals received a fluid bolus (10 ml kg(-1)), followed by stepwise bleeding (blood loss: 15 ml kg(-1)). The influence of arterial load and cardiac variables on PPV, SVV, and Eadyn was analysed using a linear mixed-effects model analysis.Results. After phenylephrine infusion, mean (SD) Eadyn decreased from 0.89 (0.14) to 0.49 (0.12), P
dc.identifier.doi10.1093/bja/aex070
dc.identifier.essn1471-6771
dc.identifier.issn0007-0912
dc.identifier.pmid28575332
dc.identifier.unpaywallURLhttp://bjanaesthesia.org/article/S0007091217300600/pdf
dc.identifier.urihttps://hdl.handle.net/10668/25040
dc.identifier.wosID402742200019
dc.issue.number6
dc.journal.titleBritish journal of anaesthesia
dc.journal.titleabbreviationBr. j. anaesth.
dc.language.isoen
dc.organizationSAS - Hospital Universitario de Jerez de la Frontera
dc.page.number938-946
dc.publisherElsevier sci ltd
dc.rights.accessRightsopen access
dc.subjectarterial pressure
dc.subjectcardiac output
dc.subjectpulse wave analysis
dc.subjectultrasonography
dc.subjectDoppler
dc.subjectPulse pressure
dc.subjectStroke volume
dc.subjectMechanical ventilation
dc.subjectFluid responsiveness
dc.subjectHemorrhage
dc.subjectVariables
dc.titleEffects of arterial load variations on dynamic arterial elastance: an experimental study
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number118
dc.wostypeArticle

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