Oxidized LDL Increase the Proinflammatory Profile of Human Visceral Adipocytes Produced by Hypoxia
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2021-11-01
Authors
Santiago-Fernandez, Concepcion
Martin-Reyes, Flores
Tome, Monica
Gutierrez-Repiso, Carolina
Fernandez-Garcia, Diego
Ocana-Wilhelmi, Luis
Rivas-Becerra, Jose
Tatzber, Franz
Pursch, Edith
Tinahones, Francisco J.
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Abstract
Background: Little is known about the effects of hypoxia on scavenger receptors (SRs) levels in adipocytes. We analyzed the effect of morbid obesity and hypoxia on SRs and inflammation markers in human visceral adipocytes and whether ox-LDL modify the inflammatory profile produced by hypoxia. Methods: We studied in 17 non-obese and 20 subjects with morbid obesity (MO) the mRNA expression of HIF-1 alpha, SRs (LOX-1, MSR1, CL-P1 and CXCL16), IL6 and TNF alpha in visceral adipocytes and the effect of hypoxia with or without ox-LDL on visceral in vitro-differentiated adipocytes (VDA). Results: HIF-1 alpha, TNF alpha, IL6, LOX-1, MSR1 and CXCL16 expression in adipocytes was increased in MO when compared with those in non-obese subjects (p
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hypoxia, scavenger receptors, oxidized LDL, adipocytes, morbid obesity, Low-density-lipoprotein, Adipose-tissue, Insulin-resistance, Oxidative stress, Scavenger receptors, Fatty-acids, Expression, Inflammation, Obesity, Atherosclerosis