RT Journal Article
T1 Oxidized LDL Increase the Proinflammatory Profile of Human Visceral Adipocytes Produced by Hypoxia
A1 Santiago-Fernandez, Concepcion
A1 Martin-Reyes, Flores
A1 Tome, Monica
A1 Gutierrez-Repiso, Carolina
A1 Fernandez-Garcia, Diego
A1 Ocana-Wilhelmi, Luis
A1 Rivas-Becerra, Jose
A1 Tatzber, Franz
A1 Pursch, Edith
A1 Tinahones, Francisco J.
A1 Garcia-Fuentes, Eduardo
A1 Garrido-Sanchez, Lourdes
K1 hypoxia
K1 scavenger receptors
K1 oxidized LDL
K1 adipocytes
K1 morbid obesity
K1 Low-density-lipoprotein
K1 Adipose-tissue
K1 Insulin-resistance
K1 Oxidative stress
K1 Scavenger receptors
K1 Fatty-acids
K1 Expression
K1 Inflammation
K1 Obesity
K1 Atherosclerosis
AB Background: Little is known about the effects of hypoxia on scavenger receptors (SRs) levels in adipocytes. We analyzed the effect of morbid obesity and hypoxia on SRs and inflammation markers in human visceral adipocytes and whether ox-LDL modify the inflammatory profile produced by hypoxia. Methods: We studied in 17 non-obese and 20 subjects with morbid obesity (MO) the mRNA expression of HIF-1 alpha, SRs (LOX-1, MSR1, CL-P1 and CXCL16), IL6 and TNF alpha in visceral adipocytes and the effect of hypoxia with or without ox-LDL on visceral in vitro-differentiated adipocytes (VDA). Results: HIF-1 alpha, TNF alpha, IL6, LOX-1, MSR1 and CXCL16 expression in adipocytes was increased in MO when compared with those in non-obese subjects (p
PB Mdpi
YR 2021
FD 2021-11-01
LK https://hdl.handle.net/10668/27079
UL https://hdl.handle.net/10668/27079
LA en
DS RISalud
RD Apr 7, 2025