Oxidized LDL Increase the Proinflammatory Profile of Human Visceral Adipocytes Produced by Hypoxia

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dc.contributor.authorSantiago-Fernandez, Concepcion
dc.contributor.authorMartin-Reyes, Flores
dc.contributor.authorTome, Monica
dc.contributor.authorGutierrez-Repiso, Carolina
dc.contributor.authorFernandez-Garcia, Diego
dc.contributor.authorOcana-Wilhelmi, Luis
dc.contributor.authorRivas-Becerra, Jose
dc.contributor.authorTatzber, Franz
dc.contributor.authorPursch, Edith
dc.contributor.authorTinahones, Francisco J.
dc.contributor.authorGarcia-Fuentes, Eduardo
dc.contributor.authorGarrido-Sanchez, Lourdes
dc.contributor.authoraffiliation[Santiago-Fernandez, Concepcion] Univ Malaga, Unidad Gest Clin Aparato Digest, Inst Invest Biomed Malaga IBIMA, Hosp Univ Virgen de la Victoria, Malaga 29010, Spain
dc.contributor.authoraffiliation[Martin-Reyes, Flores] Univ Malaga, Unidad Gest Clin Aparato Digest, Inst Invest Biomed Malaga IBIMA, Hosp Univ Virgen de la Victoria, Malaga 29010, Spain
dc.contributor.authoraffiliation[Garcia-Fuentes, Eduardo] Univ Malaga, Unidad Gest Clin Aparato Digest, Inst Invest Biomed Malaga IBIMA, Hosp Univ Virgen de la Victoria, Malaga 29010, Spain
dc.contributor.authoraffiliation[Tome, Monica] Hosp Reg Univ, Unidad Gest Clin Endocrinol & Nutr, Malaga 29010, Spain
dc.contributor.authoraffiliation[Gutierrez-Repiso, Carolina] Univ Malaga, Unidad Gest Clin Endocrinol & Nutr, Inst Invest Biomed Malaga IBIMA, Hosp Univ Virgen de la Victoria, Malaga 29010, Spain
dc.contributor.authoraffiliation[Fernandez-Garcia, Diego] Univ Malaga, Unidad Gest Clin Endocrinol & Nutr, Inst Invest Biomed Malaga IBIMA, Hosp Univ Virgen de la Victoria, Malaga 29010, Spain
dc.contributor.authoraffiliation[Tinahones, Francisco J.] Univ Malaga, Unidad Gest Clin Endocrinol & Nutr, Inst Invest Biomed Malaga IBIMA, Hosp Univ Virgen de la Victoria, Malaga 29010, Spain
dc.contributor.authoraffiliation[Garrido-Sanchez, Lourdes] Univ Malaga, Unidad Gest Clin Endocrinol & Nutr, Inst Invest Biomed Malaga IBIMA, Hosp Univ Virgen de la Victoria, Malaga 29010, Spain
dc.contributor.authoraffiliation[Fernandez-Garcia, Diego] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBERobn, Malaga 29010, Spain
dc.contributor.authoraffiliation[Tinahones, Francisco J.] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBERobn, Malaga 29010, Spain
dc.contributor.authoraffiliation[Garrido-Sanchez, Lourdes] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBERobn, Malaga 29010, Spain
dc.contributor.authoraffiliation[Ocana-Wilhelmi, Luis] Hosp Univ Virgen de la Victoria, Unidad Gest Clin Cirugia Gen & Digest, Malaga 29010, Spain
dc.contributor.authoraffiliation[Rivas-Becerra, Jose] Hosp Reg Univ, Unidad Gest Clin Cirugia Gen Digest & Trasplantes, Malaga 29010, Spain
dc.contributor.authoraffiliation[Tatzber, Franz] Med Univ Graz, Otto Loewi Res Ctr, Div Immunol & Pathophysiol, A-8010 Graz, Austria
dc.contributor.authoraffiliation[Pursch, Edith] Univ Appl Sci Tech Wien, Inst Biochem Engn, A-1200 Vienna, Austria
dc.contributor.authoraffiliation[Garcia-Fuentes, Eduardo] Inst Salud Carlos III, CIBER Enfermedades Hepat & Digest CIBERehd, Malaga 29010, Spain
dc.contributor.funderInstituto de Salud Carlos III (Spain)
dc.contributor.funderFEDER funds ("A way to make Europe")
dc.date.accessioned2025-01-07T15:22:18Z
dc.date.available2025-01-07T15:22:18Z
dc.date.issued2021-11-01
dc.description.abstractBackground: Little is known about the effects of hypoxia on scavenger receptors (SRs) levels in adipocytes. We analyzed the effect of morbid obesity and hypoxia on SRs and inflammation markers in human visceral adipocytes and whether ox-LDL modify the inflammatory profile produced by hypoxia. Methods: We studied in 17 non-obese and 20 subjects with morbid obesity (MO) the mRNA expression of HIF-1 alpha, SRs (LOX-1, MSR1, CL-P1 and CXCL16), IL6 and TNF alpha in visceral adipocytes and the effect of hypoxia with or without ox-LDL on visceral in vitro-differentiated adipocytes (VDA). Results: HIF-1 alpha, TNF alpha, IL6, LOX-1, MSR1 and CXCL16 expression in adipocytes was increased in MO when compared with those in non-obese subjects (p
dc.identifier.doi10.3390/biomedicines9111715
dc.identifier.essn2227-9059
dc.identifier.pmid34829944
dc.identifier.unpaywallURLhttps://www.mdpi.com/2227-9059/9/11/1715/pdf?version=1637239601
dc.identifier.urihttps://hdl.handle.net/10668/27079
dc.identifier.wosID724191700001
dc.issue.number11
dc.journal.titleBiomedicines
dc.journal.titleabbreviationBiomedicines
dc.language.isoen
dc.organizationSAS - Hospital Universitario Virgen de la Victoria
dc.organizationSAS - Hospital Universitario Virgen de la Victoria
dc.organizationSAS - Hospital Universitario Regional de Málaga
dc.organizationSAS - Hospital Universitario Regional de Málaga
dc.organizationInstituto de Investigación Biomédica de Málaga - Plataforma Bionand (IBIMA)
dc.publisherMdpi
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjecthypoxia
dc.subjectscavenger receptors
dc.subjectoxidized LDL
dc.subjectadipocytes
dc.subjectmorbid obesity
dc.subjectLow-density-lipoprotein
dc.subjectAdipose-tissue
dc.subjectInsulin-resistance
dc.subjectOxidative stress
dc.subjectScavenger receptors
dc.subjectFatty-acids
dc.subjectExpression
dc.subjectInflammation
dc.subjectObesity
dc.subjectAtherosclerosis
dc.titleOxidized LDL Increase the Proinflammatory Profile of Human Visceral Adipocytes Produced by Hypoxia
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number9
dc.wostypeArticle

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