Evolution of Metabolic Phenotypes of Obesity in Coronary Patients after 5 Years of Dietary Intervention: From the CORDIOPREV Study
No Thumbnail Available
Identifiers
Date
2021-11-01
Authors
Martin-Piedra, Laura
Alcala-Diaz, Juan F.
Gutierrez-Mariscal, Francisco M.
Arenas de Larriva, Antonio P.
Romero-Cabrera, Juan L.
Torres-Pena, Jose D.
Caballero-Villarraso, Javier
Luque, Raul M.
Perez-Martinez, Pablo
Lopez-Miranda, Jose
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
Mdpi
Metrics
Export
Abstract
Background: Obesity phenotypes with different metabolic status have been described previously. We analyzed metabolic phenotypes in obese coronary patients during a 5-year follow-up, and examined the factors influencing this evolution. Methods: The CORDIOPREV study is a randomized, long-term secondary prevention study with two healthy diets: Mediterranean and low-fat. All obese patients were classified as either metabolically healthy obese (MHO) or metabolically unhealthy obese (MUO). We evaluated the changes in the metabolic phenotypes and related variables after 5 years of dietary intervention. Results: Initially, 562 out of the 1002 CORDIOPREV patients were obese. After 5 years, 476 obese patients maintained their clinical and dietary visits; 71.8% of MHO patients changed to unhealthy phenotypes (MHO-Progressors), whereas the MHO patients who maintained healthy phenotypes (MHO-Non-Progressors) lost more in terms of their body mass index (BMI) and had a lower fatty liver index (FLI-score) (p
Description
MeSH Terms
DeCS Terms
CIE Terms
Keywords
obesity metabolic phenotypes, metabolically healthy obese, metabolically unhealthy obese, fatty liver index, diet intervention, Mediterranean diet, low-fat diet, coronary patients, Body-fat distribution, Healthy obesity, Adipose-tissue, Cardiovascular-disease, European-society, Task-force, Inflammation, Association, Prevention, Mass