%0 Journal Article
%A Martin-Piedra, Laura
%A Alcala-Diaz, Juan F.
%A Gutierrez-Mariscal, Francisco M.
%A Arenas de Larriva, Antonio P.
%A Romero-Cabrera, Juan L.
%A Torres-Pena, Jose D.
%A Caballero-Villarraso, Javier
%A Luque, Raul M.
%A Perez-Martinez, Pablo
%A Lopez-Miranda, Jose
%A Delgado-Lista, Javier
%T Evolution of Metabolic Phenotypes of Obesity in Coronary Patients after 5 Years of Dietary Intervention: From the CORDIOPREV Study
%D 2021
%U https://hdl.handle.net/10668/25863
%X Background: Obesity phenotypes with different metabolic status have been described previously. We analyzed metabolic phenotypes in obese coronary patients during a 5-year follow-up, and examined the factors influencing this evolution. Methods: The CORDIOPREV study is a randomized, long-term secondary prevention study with two healthy diets: Mediterranean and low-fat. All obese patients were classified as either metabolically healthy obese (MHO) or metabolically unhealthy obese (MUO). We evaluated the changes in the metabolic phenotypes and related variables after 5 years of dietary intervention. Results: Initially, 562 out of the 1002 CORDIOPREV patients were obese. After 5 years, 476 obese patients maintained their clinical and dietary visits; 71.8% of MHO patients changed to unhealthy phenotypes (MHO-Progressors), whereas the MHO patients who maintained healthy phenotypes (MHO-Non-Progressors) lost more in terms of their body mass index (BMI) and had a lower fatty liver index (FLI-score) (p
%K obesity metabolic phenotypes
%K metabolically healthy obese
%K metabolically unhealthy obese
%K fatty liver index
%K diet intervention
%K Mediterranean diet
%K low-fat diet
%K coronary patients
%K Body-fat distribution
%K Healthy obesity
%K Adipose-tissue
%K Cardiovascular-disease
%K European-society
%K Task-force
%K Inflammation
%K Association
%K Prevention
%K Mass
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