Performance of a Quantitative PCR-Based Assay and Beta-D-Glucan Detection for Diagnosis of Invasive Candidiasis in Very-Low-Birth-Weight Preterm Neonatal Patients (CANDINEO Study)
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2017-09-01
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Tomas Ramos, Jose
Villar, Sonia
Bouza, Emilio
Bergon-Sendin, Elena
Perez Rivilla, Alfredo
Tapia Collados, Caridad
Andreu, Mariano
Santana Reyes, Candelaria
Isolina Campos-Herrero, Maria
Lopez de Heredia, Jon
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Amer soc microbiology
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Abstract
An epidemiological, multicenter, noninterventional, observational casecontrol study was conducted to describe the performance of serum beta-D-glucan (BDG) and Candida PCR in blood, serum, and sterile samples for the diagnosis of invasive candidiasis (IC) in very-low-birth-weight (VLBW) preterm neonates and to compare these techniques with culture of samples from blood and other sterile sites. Seventeen centers participated in the study, and the number of episodes analyzed was 159. A total of 9 episodes of IC from 9 patients (7 confirmed and 2 probable) and 150 episodes of suspected sepsis from 117 controls were identified. The prevalence of IC was 5.7% (95% confidence interval [95% CI], 2.1 to 9.3). The mortality was significantly higher in episodes of IC (44.4%) than in the non-IC episodes (11.1%, P
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invasive candidiasis, serum beta-D-glucan, PCR, polymerase chain reaction, Care-unit patients, Real-time pcr, Pediatric-patients, Blood culture, Risk-factors, Infants, Infections, Candidemia, Dna, Identification