RT Journal Article
T1 Performance of a Quantitative PCR-Based Assay and Beta-D-Glucan Detection for Diagnosis of Invasive Candidiasis in Very-Low-Birth-Weight Preterm Neonatal Patients (CANDINEO Study)
A1 Tomas Ramos, Jose
A1 Villar, Sonia
A1 Bouza, Emilio
A1 Bergon-Sendin, Elena
A1 Perez Rivilla, Alfredo
A1 Tapia Collados, Caridad
A1 Andreu, Mariano
A1 Santana Reyes, Candelaria
A1 Isolina Campos-Herrero, Maria
A1 Lopez de Heredia, Jon
A1 Lopez Herrera, Maria Cruz
A1 Anguita Alonso, Paloma
A1 Rosa Pallas-Alonso, Carmen
A1 Cuenca-Estrella, Manuel
A1 CANDINEO Study Grp, 
K1 invasive candidiasis
K1 serum beta-D-glucan
K1 PCR
K1 polymerase chain reaction
K1 Care-unit patients
K1 Real-time pcr
K1 Pediatric-patients
K1 Blood culture
K1 Risk-factors
K1 Infants
K1 Infections
K1 Candidemia
K1 Dna
K1 Identification
AB An epidemiological, multicenter, noninterventional, observational casecontrol study was conducted to describe the performance of serum beta-D-glucan (BDG) and Candida PCR in blood, serum, and sterile samples for the diagnosis of invasive candidiasis (IC) in very-low-birth-weight (VLBW) preterm neonates and to compare these techniques with culture of samples from blood and other sterile sites. Seventeen centers participated in the study, and the number of episodes analyzed was 159. A total of 9 episodes of IC from 9 patients (7 confirmed and 2 probable) and 150 episodes of suspected sepsis from 117 controls were identified. The prevalence of IC was 5.7% (95% confidence interval [95% CI], 2.1 to 9.3). The mortality was significantly higher in episodes of IC (44.4%) than in the non-IC episodes (11.1%, P
PB Amer soc microbiology
SN 0095-1137
YR 2017
FD 2017-09-01
LK https://hdl.handle.net/10668/25415
UL https://hdl.handle.net/10668/25415
LA en
DS RISalud
RD Apr 5, 2025