Performance of a Quantitative PCR-Based Assay and Beta-D-Glucan Detection for Diagnosis of Invasive Candidiasis in Very-Low-Birth-Weight Preterm Neonatal Patients (CANDINEO Study)

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dc.contributor.authorTomas Ramos, Jose
dc.contributor.authorVillar, Sonia
dc.contributor.authorBouza, Emilio
dc.contributor.authorBergon-Sendin, Elena
dc.contributor.authorPerez Rivilla, Alfredo
dc.contributor.authorTapia Collados, Caridad
dc.contributor.authorAndreu, Mariano
dc.contributor.authorSantana Reyes, Candelaria
dc.contributor.authorIsolina Campos-Herrero, Maria
dc.contributor.authorLopez de Heredia, Jon
dc.contributor.authorLopez Herrera, Maria Cruz
dc.contributor.authorAnguita Alonso, Paloma
dc.contributor.authorRosa Pallas-Alonso, Carmen
dc.contributor.authorCuenca-Estrella, Manuel
dc.contributor.authorCANDINEO Study Grp
dc.contributor.authoraffiliation[Tomas Ramos, Jose] Hosp Univ Clin San Carlos, Dept Pediat, Madrid, Spain
dc.contributor.authoraffiliation[Tomas Ramos, Jose] Univ Complutense, Inst Invest Sanitaria Hosp Clin San Carols IdISSC, Madrid, Spain
dc.contributor.authoraffiliation[Villar, Sonia] Hosp Materno Infantil Gregorio Maranon, Serv Neonatol, Madrid, Spain
dc.contributor.authoraffiliation[Bouza, Emilio] Univ Complutense Madrid, IISGM, CIBERES, Hosp Gen Univ Gregorio Maranon, Madrid, Spain
dc.contributor.authoraffiliation[Bergon-Sendin, Elena] Univ Complutense, Hosp Univ Octubre 12, Serv Neonatol, Madrid, Spain
dc.contributor.authoraffiliation[Rosa Pallas-Alonso, Carmen] Univ Complutense, Hosp Univ Octubre 12, Serv Neonatol, Madrid, Spain
dc.contributor.authoraffiliation[Bergon-Sendin, Elena] Red Salud Materno Infantil & Desarrollo SAMID, Madrid, Spain
dc.contributor.authoraffiliation[Rosa Pallas-Alonso, Carmen] Red Salud Materno Infantil & Desarrollo SAMID, Madrid, Spain
dc.contributor.authoraffiliation[Perez Rivilla, Alfredo] Hosp Univ 12 Octubre, Serv Microbiol, Madrid, Spain
dc.contributor.authoraffiliation[Tapia Collados, Caridad] Hosp Gen Univ Alicante, Serv Neonatol, Alicante, Spain
dc.contributor.authoraffiliation[Andreu, Mariano] Hosp Gen Univ Alicante, Serv Microbiol, Alicante, Spain
dc.contributor.authoraffiliation[Santana Reyes, Candelaria] Hosp Materno Infantil Insular Las Palmas, Serv Neonatol, Las Palmas Gran Canaria, Spain
dc.contributor.authoraffiliation[Isolina Campos-Herrero, Maria] Hosp Univ Gran Canaria Doctor Negrin, Hosp Materno Infantil, Serv Microbiol, Las Palmas Gran Canaria, Spain
dc.contributor.authoraffiliation[Lopez de Heredia, Jon] Hosp Cruces, Serv Neonatol, Bilbao, Spain
dc.contributor.authoraffiliation[Lopez Herrera, Maria Cruz] Hosp Cruces, Serv Neonatol, Bilbao, Spain
dc.contributor.authoraffiliation[Anguita Alonso, Paloma] Astellas Pharma SA, Madrid, Spain
dc.contributor.authoraffiliation[Cuenca-Estrella, Manuel] Inst Salud Carlos III, Madrid, Spain
dc.contributor.authoraffiliation[Cuenca-Estrella, Manuel] Inst Salud Carlos III, Spanish Natl Ctr Microbiol, Mycol Dept, Madrid, Spain
dc.contributor.funderAstellas Pharma Inc.
dc.contributor.funderbioMerieux
dc.contributor.funderBasilea
dc.contributor.funderGilead Sciences
dc.contributor.funderMerck Sharp Dohme
dc.contributor.funderPfizer
dc.contributor.funderSchering Plough
dc.contributor.funderSoria Melguizo SA
dc.contributor.funderFerrer International
dc.contributor.funderEuropean Union
dc.contributor.funderALBAN program
dc.contributor.funderSpanish Agency for International Cooperation
dc.contributor.funderSpanish Ministry of Culture and Education
dc.contributor.funderSpanish Health Research Fund
dc.contributor.funderInstituto de Salud Carlos III (Spanish Ministry of Economy and Competitiveness)
dc.contributor.funderRamon Areces Foundation
dc.contributor.funderMutua Madrilena Foundation
dc.contributor.funderViiV Healthcare
dc.contributor.funderJanssen-Cilag
dc.contributor.funderGilead Fellowship Program
dc.date.accessioned2025-01-07T13:19:37Z
dc.date.available2025-01-07T13:19:37Z
dc.date.issued2017-09-01
dc.description.abstractAn epidemiological, multicenter, noninterventional, observational casecontrol study was conducted to describe the performance of serum beta-D-glucan (BDG) and Candida PCR in blood, serum, and sterile samples for the diagnosis of invasive candidiasis (IC) in very-low-birth-weight (VLBW) preterm neonates and to compare these techniques with culture of samples from blood and other sterile sites. Seventeen centers participated in the study, and the number of episodes analyzed was 159. A total of 9 episodes of IC from 9 patients (7 confirmed and 2 probable) and 150 episodes of suspected sepsis from 117 controls were identified. The prevalence of IC was 5.7% (95% confidence interval [95% CI], 2.1 to 9.3). The mortality was significantly higher in episodes of IC (44.4%) than in the non-IC episodes (11.1%, P
dc.identifier.doi10.1128/JCM.00496-17
dc.identifier.essn1098-660X
dc.identifier.issn0095-1137
dc.identifier.pmid28659321
dc.identifier.unpaywallURLhttps://jcm.asm.org/content/jcm/55/9/2752.full.pdf
dc.identifier.urihttps://hdl.handle.net/10668/25415
dc.identifier.wosID408223700021
dc.issue.number9
dc.journal.titleJournal of clinical microbiology
dc.journal.titleabbreviationJ. clin. microbiol.
dc.language.isoen
dc.organizationSAS - Hospital Universitario Reina Sofía
dc.page.number2752-2764
dc.publisherAmer soc microbiology
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectinvasive candidiasis
dc.subjectserum beta-D-glucan
dc.subjectPCR
dc.subjectpolymerase chain reaction
dc.subjectCare-unit patients
dc.subjectReal-time pcr
dc.subjectPediatric-patients
dc.subjectBlood culture
dc.subjectRisk-factors
dc.subjectInfants
dc.subjectInfections
dc.subjectCandidemia
dc.subjectDna
dc.subjectIdentification
dc.titlePerformance of a Quantitative PCR-Based Assay and Beta-D-Glucan Detection for Diagnosis of Invasive Candidiasis in Very-Low-Birth-Weight Preterm Neonatal Patients (CANDINEO Study)
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number55
dc.wostypeArticle

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