Metabolic Fingerprint of Acromegaly and its Potential Usefulness in Clinical Practice.
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2019-09-26
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Biagetti, Betina
Herance, J R
Ferrer, Roser
Aulinas, Anna
Palomino-Schätzlein, Martina
Mesa, Jordi
Castaño, J P
Luque, Raul M
Simó, Rafael
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Abstract
Insulin-like growth factor-1 (IGF-1) and growth hormone (GH) levels are the main targets for monitoring acromegaly activity, but they are not in close relationship with the clinical course of the disease and the associated comorbidities. The present study was aimed at identifying metabolites that could be used as biomarkers for a better disease phenotyping. For this purpose, metabolic fingerprint using an untargeted metabolomic approach was examined in serum from 30 patients with acromegaly and 30 age-matched controls. Patients with acromegaly presented fewer branched-chain amino acids (BCAAs) compared to the control group (valine: 4.75 ± 0.87 vs. 5.20 ± 1.06 arbitrary units (AUs), p
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acromegaly, amino acids, branched chain, insulin resistance, metabolomics, muscular weakness