RT Journal Article
T1 Metabolic Fingerprint of Acromegaly and its Potential Usefulness in Clinical Practice.
A1 Biagetti, Betina
A1 Herance, J R
A1 Ferrer, Roser
A1 Aulinas, Anna
A1 Palomino-Schätzlein, Martina
A1 Mesa, Jordi
A1 Castaño, J P
A1 Luque, Raul M
A1 Simó, Rafael
K1 acromegaly
K1 amino acids
K1 branched chain
K1 insulin resistance
K1 metabolomics
K1 muscular weakness
AB Insulin-like growth factor-1 (IGF-1) and growth hormone (GH) levels are the main targets for monitoring acromegaly activity, but they are not in close relationship with the clinical course of the disease and the associated comorbidities. The present study was aimed at identifying metabolites that could be used as biomarkers for a better disease phenotyping. For this purpose, metabolic fingerprint using an untargeted metabolomic approach was examined in serum from 30 patients with acromegaly and 30 age-matched controls. Patients with acromegaly presented fewer branched-chain amino acids (BCAAs) compared to the control group (valine: 4.75 ± 0.87 vs. 5.20 ± 1.06 arbitrary units (AUs), p
SN 2077-0383
YR 2019
FD 2019-09-26
LK https://hdl.handle.net/10668/25810
UL https://hdl.handle.net/10668/25810
LA en
DS RISalud
RD Apr 11, 2025