Metabolic Fingerprint of Acromegaly and its Potential Usefulness in Clinical Practice.

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dc.contributor.authorBiagetti, Betina
dc.contributor.authorHerance, J R
dc.contributor.authorFerrer, Roser
dc.contributor.authorAulinas, Anna
dc.contributor.authorPalomino-Schätzlein, Martina
dc.contributor.authorMesa, Jordi
dc.contributor.authorCastaño, J P
dc.contributor.authorLuque, Raul M
dc.contributor.authorSimó, Rafael
dc.date.accessioned2025-01-07T13:44:15Z
dc.date.available2025-01-07T13:44:15Z
dc.date.issued2019-09-26
dc.description.abstractInsulin-like growth factor-1 (IGF-1) and growth hormone (GH) levels are the main targets for monitoring acromegaly activity, but they are not in close relationship with the clinical course of the disease and the associated comorbidities. The present study was aimed at identifying metabolites that could be used as biomarkers for a better disease phenotyping. For this purpose, metabolic fingerprint using an untargeted metabolomic approach was examined in serum from 30 patients with acromegaly and 30 age-matched controls. Patients with acromegaly presented fewer branched-chain amino acids (BCAAs) compared to the control group (valine: 4.75 ± 0.87 vs. 5.20 ± 1.06 arbitrary units (AUs), p
dc.identifier.doi10.3390/jcm8101549
dc.identifier.issn2077-0383
dc.identifier.pmcPMC6832216
dc.identifier.pmid31561638
dc.identifier.pubmedURLhttps://pmc.ncbi.nlm.nih.gov/articles/PMC6832216/pdf
dc.identifier.unpaywallURLhttps://www.mdpi.com/2077-0383/8/10/1549/pdf?version=1570525055
dc.identifier.urihttps://hdl.handle.net/10668/25810
dc.issue.number10
dc.journal.titleJournal of clinical medicine
dc.journal.titleabbreviationJ Clin Med
dc.language.isoen
dc.organizationSAS - Hospital Universitario Reina Sofía
dc.organizationSAS - Hospital Universitario Reina Sofía
dc.organizationInstituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC)
dc.pubmedtypeJournal Article
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectacromegaly
dc.subjectamino acids
dc.subjectbranched chain
dc.subjectinsulin resistance
dc.subjectmetabolomics
dc.subjectmuscular weakness
dc.titleMetabolic Fingerprint of Acromegaly and its Potential Usefulness in Clinical Practice.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number8

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