Melatonin Improves Levels of Zn and Cu in the Muscle of Diabetic Obese Rats.
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2021-09-22
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Navarro-Alarcón, Miguel
Gil-Hernández, Fernando
Sánchez-González, Cristina
Llopis, Juan
Villalón-Mir, Marina
Olmedo, Pablo
Alarcón-Guijo, Pablo
Salagre, Diego
Gaona, Lorena
Paredes, Mario
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Abstract
Melatonin improves metabolic alterations associated with obesity and its diabetes (diabesity). We intend to determine whether this improvement is exerted by changing Zn and/or Cu tissue levels in liver, muscle, pancreas, and brain, and in internal (perirenal, perigonadal, and omentum) and subcutaneous lumbar white adipose tissues (IWAT and SWAT, respectively). Male Zücker diabetic fatty (ZDF) rats and lean littermates (ZL) were orally supplemented either with melatonin (10 mg/kg body weight/day) or vehicle for 6 weeks. Zn and Cu concentrations were not significantly influenced by diabesity in the analyzed tissues (p > 0.05), with the exception of Zn in liver. In skeletal muscle Zn and Cu, and in perirenal WAT, only Zn levels increased significantly with melatonin supplementation in ZDF rats (p 0.05), with the exception of Zn in liver. In skeletal muscle Zn and Cu, and in perirenal WAT, only Zn levels increased significantly with melatonin supplementation in ZDF rats (p
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copper, diabetic obese rat, melatonin, muscle and other organ and white adipose tissues, zinc