Melatonin Improves Levels of Zn and Cu in the Muscle of Diabetic Obese Rats.

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dc.contributor.authorNavarro-Alarcón, Miguel
dc.contributor.authorGil-Hernández, Fernando
dc.contributor.authorSánchez-González, Cristina
dc.contributor.authorLlopis, Juan
dc.contributor.authorVillalón-Mir, Marina
dc.contributor.authorOlmedo, Pablo
dc.contributor.authorAlarcón-Guijo, Pablo
dc.contributor.authorSalagre, Diego
dc.contributor.authorGaona, Lorena
dc.contributor.authorParedes, Mario
dc.contributor.authorAgil, Ahmad
dc.date.accessioned2025-01-07T17:04:27Z
dc.date.available2025-01-07T17:04:27Z
dc.date.issued2021-09-22
dc.description.abstractMelatonin improves metabolic alterations associated with obesity and its diabetes (diabesity). We intend to determine whether this improvement is exerted by changing Zn and/or Cu tissue levels in liver, muscle, pancreas, and brain, and in internal (perirenal, perigonadal, and omentum) and subcutaneous lumbar white adipose tissues (IWAT and SWAT, respectively). Male Zücker diabetic fatty (ZDF) rats and lean littermates (ZL) were orally supplemented either with melatonin (10 mg/kg body weight/day) or vehicle for 6 weeks. Zn and Cu concentrations were not significantly influenced by diabesity in the analyzed tissues (p > 0.05), with the exception of Zn in liver. In skeletal muscle Zn and Cu, and in perirenal WAT, only Zn levels increased significantly with melatonin supplementation in ZDF rats (p 0.05), with the exception of Zn in liver. In skeletal muscle Zn and Cu, and in perirenal WAT, only Zn levels increased significantly with melatonin supplementation in ZDF rats (p
dc.identifier.doi10.3390/pharmaceutics13101535
dc.identifier.issn1999-4923
dc.identifier.pmcPMC8539996
dc.identifier.pmid34683825
dc.identifier.pubmedURLhttps://pmc.ncbi.nlm.nih.gov/articles/PMC8539996/pdf
dc.identifier.unpaywallURLhttps://www.mdpi.com/1999-4923/13/10/1535/pdf?version=1634202936
dc.identifier.urihttps://hdl.handle.net/10668/28159
dc.issue.number10
dc.journal.titlePharmaceutics
dc.journal.titleabbreviationPharmaceutics
dc.language.isoen
dc.organizationInstituto de Investigación Biosanitaria de Granada (ibs.GRANADA)
dc.organizationSAS - Hospital Universitario San Cecilio
dc.organizationInstituto de Investigación Biosanitaria de Granada (ibs.GRANADA)
dc.pubmedtypeJournal Article
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectcopper
dc.subjectdiabetic obese rat
dc.subjectmelatonin
dc.subjectmuscle and other organ and white adipose tissues
dc.subjectzinc
dc.titleMelatonin Improves Levels of Zn and Cu in the Muscle of Diabetic Obese Rats.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number13

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