RT Journal Article
T1 Melatonin Improves Levels of Zn and Cu in the Muscle of Diabetic Obese Rats.
A1 Navarro-Alarcón, Miguel
A1 Gil-Hernández, Fernando
A1 Sánchez-González, Cristina
A1 Llopis, Juan
A1 Villalón-Mir, Marina
A1 Olmedo, Pablo
A1 Alarcón-Guijo, Pablo
A1 Salagre, Diego
A1 Gaona, Lorena
A1 Paredes, Mario
A1 Agil, Ahmad
K1 copper
K1 diabetic obese rat
K1 melatonin
K1 muscle and other organ and white adipose tissues
K1 zinc
AB Melatonin improves metabolic alterations associated with obesity and its diabetes (diabesity). We intend to determine whether this improvement is exerted by changing Zn and/or Cu tissue levels in liver, muscle, pancreas, and brain, and in internal (perirenal, perigonadal, and omentum) and subcutaneous lumbar white adipose tissues (IWAT and SWAT, respectively). Male Zücker diabetic fatty (ZDF) rats and lean littermates (ZL) were orally supplemented either with melatonin (10 mg/kg body weight/day) or vehicle for 6 weeks. Zn and Cu concentrations were not significantly influenced by diabesity in the analyzed tissues (p > 0.05), with the exception of Zn in liver. In skeletal muscle Zn and Cu, and in perirenal WAT, only Zn levels increased significantly with melatonin supplementation in ZDF rats (p  0.05), with the exception of Zn in liver. In skeletal muscle Zn and Cu, and in perirenal WAT, only Zn levels increased significantly with melatonin supplementation in ZDF rats (p
SN 1999-4923
YR 2021
FD 2021-09-22
LK https://hdl.handle.net/10668/28159
UL https://hdl.handle.net/10668/28159
LA en
DS RISalud
RD Apr 11, 2025