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http://hdl.handle.net/10668/4599| Title: | Non-Coding RNAs in Kidney Diseases: The Long and Short of Them |
| Authors: | Moreno, Juan Antonio Hamza, Eya Guerrero-Hue, Melania Rayego-Mateos, Sandra García-Caballero, Cristina Vallejo-Mudarra, Mercedes Metzinger, Laurent Metzinger-Le Meuth, Valérie |
| metadata.dc.contributor.authoraffiliation: | [Moreno,JA; Guerrero-Hue,M; García-Caballero,C; Vallejo-Mudarra,M] Maimonides Biomedical Research Institute of Cordoba (IMIBIC), UGC Nephrology, Hospital Universitario Reina Sofía, Córdoba, Spain. [Moreno,JA] Biomedical Research Networking Center on Cardiovascular Diseases (CIBERCV), Madrid, Spain. [Moreno,JA] Department of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain. [Hamza,E; Metzinger,L; Metzinger-Le Meuth,V] HEMATIM UR 4666, C.U.R.S, Université de Picardie Jules Verne (UPJV), CEDEX 1, Amiens, France. [Rayego-Mateos,S] Renal, Vascular and Diabetes Research Laboratory, IIS-Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Madrid, Spain. [Metzinger-Le Meuth,V] INSERM UMRS 1148, Laboratory for Vascular Translational Science (LVTS), UFR SMBH, Université Sorbonne Paris Nord, CEDEX, Bobigny, France. |
| Keywords: | Non-coding RNA;MicroRNA;Long non-coding RNA;Chronic kidney disease;Acute kidney disease;IgA nephropathy;Gene regulation;ARN no traducido;MicroARNs;ARN largo no codificante;Insuficiencia renal crónica;Enfermedades renales;Glomerulonefritis por IgA;Regulación de la expresión génica |
| metadata.dc.subject.mesh: | Medical Subject Headings::Organisms::Eukaryota::Animals Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::RNA::RNA, Untranslated::RNA, Long Noncoding Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::RNA::RNA, Messenger Medical Subject Headings::Diseases::Male Urogenital Diseases::Urologic Diseases::Kidney Diseases::Renal Insufficiency::Renal Insufficiency, Chronic Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Antisense Elements (Genetics)::Oligonucleotides, Antisense Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::DNA, Intergenic Medical Subject Headings::Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Biology::Computational Biology::Genomics Medical Subject Headings::Diseases::Male Urogenital Diseases::Urologic Diseases::Kidney Diseases Medical Subject Headings::Diseases::Female Urogenital Diseases and Pregnancy Complications::Female Urogenital Diseases::Urologic Diseases::Kidney Diseases Medical Subject Headings::Chemicals and Drugs::Biological Factors::Biological Markers Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics |
| Issue Date: | 4-Jun-2021 |
| Publisher: | MDPI |
| Citation: | Moreno JA, Hamza E, Guerrero-Hue M, Rayego-Mateos S, García-Caballero C, Vallejo-Mudarra M, et al. Non-Coding RNAs in Kidney Diseases: The Long and Short of Them. Int J Mol Sci. 2021 Jun 4;22(11):6077 |
| Abstract: | Recent progress in genomic research has highlighted the genome to be much more transcribed than expected. The formerly so-called junk DNA encodes a miscellaneous group of largely unknown RNA transcripts, which contain the long non-coding RNAs (lncRNAs) family. lncRNAs are instrumental in gene regulation. Moreover, understanding their biological roles in the physiopathology of many diseases, including renal, is a new challenge. lncRNAs regulate the effects of microRNAs (miRNA) on mRNA expression. Understanding the complex crosstalk between lncRNA-miRNA-mRNA is one of the main challenges of modern molecular biology. This review aims to summarize the role of lncRNA on kidney diseases, the molecular mechanisms involved, and their function as emerging prognostic biomarkers for both acute and chronic kidney diseases. Finally, we will also outline new therapeutic opportunities to diminish renal injury by targeting lncRNA with antisense oligonucleotides. |
| URI: | http://hdl.handle.net/10668/4599 |
| metadata.dc.relation.publisherversion: | https://www.mdpi.com/1422-0067/22/11/6077 |
| metadata.dc.identifier.doi: | 10.3390/ijms22116077 |
| ISSN: | 1422-0067 (Online) |
| Appears in Collections: | 01- Artículos - Hospital Reina Sofía 01- Artículos - IMIBIC. Instituto Maimónides de Investigación Biomédica de Córdoba |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| Moreno_NonCodingRNAs.pdf | Revisión | 725,11 kB | Adobe PDF | View/Open |
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