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Non-Coding RNAs in Kidney Diseases: The Long and Short of Them

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dc.contributor.authorMoreno, Juan Antonio
dc.contributor.authorHamza, Eya
dc.contributor.authorGuerrero-Hue, Melania
dc.contributor.authorRayego-Mateos, Sandra
dc.contributor.authorGarcía-Caballero, Cristina
dc.contributor.authorVallejo-Mudarra, Mercedes
dc.contributor.authorMetzinger, Laurent
dc.contributor.authorMetzinger-Le Meuth, Valérie
dc.contributor.authoraffiliation[Moreno,JA; Guerrero-Hue,M; García-Caballero,C; Vallejo-Mudarra,M] Maimonides Biomedical Research Institute of Cordoba (IMIBIC), UGC Nephrology, Hospital Universitario Reina Sofía, Córdoba, Spain. [Moreno,JA] Biomedical Research Networking Center on Cardiovascular Diseases (CIBERCV), Madrid, Spain. [Moreno,JA] Department of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain. [Hamza,E; Metzinger,L; Metzinger-Le Meuth,V] HEMATIM UR 4666, C.U.R.S, Université de Picardie Jules Verne (UPJV), CEDEX 1, Amiens, France. [Rayego-Mateos,S] Renal, Vascular and Diabetes Research Laboratory, IIS-Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Madrid, Spain. [Metzinger-Le Meuth,V] INSERM UMRS 1148, Laboratory for Vascular Translational Science (LVTS), UFR SMBH, Université Sorbonne Paris Nord, CEDEX, Bobigny, France.
dc.contributor.funderThis research was funded by SFNDT, Vifor. (L.M., V.M.-L.M. and E.H.), Instituto de Salud Carlos III (ISCIII, FIS-FEDER PI17/00130 and PI20/00375), Spanish Biomedical Research Centre in Cardiovascular Diseases (CIBERCV), Spanish Ministry of Science and Innovation (RYC-2017-22369), and Spanish Society of Nephrology (SEN). The “PFIS” and “Sara Borrell” training program of the ISCIII supported the salary of MGH (FI18/00310) and SR-M (CD19/00021).
dc.date.accessioned2023-01-19T13:33:45Z
dc.date.available2023-01-19T13:33:45Z
dc.date.issued2021-06-04
dc.description.abstractRecent progress in genomic research has highlighted the genome to be much more transcribed than expected. The formerly so-called junk DNA encodes a miscellaneous group of largely unknown RNA transcripts, which contain the long non-coding RNAs (lncRNAs) family. lncRNAs are instrumental in gene regulation. Moreover, understanding their biological roles in the physiopathology of many diseases, including renal, is a new challenge. lncRNAs regulate the effects of microRNAs (miRNA) on mRNA expression. Understanding the complex crosstalk between lncRNA-miRNA-mRNA is one of the main challenges of modern molecular biology. This review aims to summarize the role of lncRNA on kidney diseases, the molecular mechanisms involved, and their function as emerging prognostic biomarkers for both acute and chronic kidney diseases. Finally, we will also outline new therapeutic opportunities to diminish renal injury by targeting lncRNA with antisense oligonucleotides.es_ES
dc.description.versionYeses_ES
dc.identifier.citationMoreno JA, Hamza E, Guerrero-Hue M, Rayego-Mateos S, García-Caballero C, Vallejo-Mudarra M, et al. Non-Coding RNAs in Kidney Diseases: The Long and Short of Them. Int J Mol Sci. 2021 Jun 4;22(11):6077es_ES
dc.identifier.doi10.3390/ijms22116077es_ES
dc.identifier.essn1422-0067
dc.identifier.pmcPMC8200121
dc.identifier.pmid34199920es_ES
dc.identifier.urihttp://hdl.handle.net/10668/4599
dc.journal.titleInternational Journal of Molecular Sciences
dc.language.isoen
dc.page.number19 p.
dc.publisherMDPIes_ES
dc.relation.publisherversionhttps://www.mdpi.com/1422-0067/22/11/6077es_ES
dc.rightsAtribución 4.0 Internacional*
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectNon-coding RNAes_ES
dc.subjectMicroRNAes_ES
dc.subjectLong non-coding RNAes_ES
dc.subjectChronic kidney diseasees_ES
dc.subjectAcute kidney diseasees_ES
dc.subjectIgA nephropathyes_ES
dc.subjectGene regulationes_ES
dc.subjectARN no traducidoes_ES
dc.subjectMicroARNses_ES
dc.subjectARN largo no codificantees_ES
dc.subjectInsuficiencia renal crónicaes_ES
dc.subjectEnfermedades renaleses_ES
dc.subjectGlomerulonefritis por IgAes_ES
dc.subjectRegulación de la expresión génicaes_ES
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animalses_ES
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humanses_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::RNA::RNA, Untranslated::RNA, Long Noncodinges_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::RNA::RNA, Messengeres_ES
dc.subject.meshMedical Subject Headings::Diseases::Male Urogenital Diseases::Urologic Diseases::Kidney Diseases::Renal Insufficiency::Renal Insufficiency, Chronices_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulationes_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Antisense Elements (Genetics)::Oligonucleotides, Antisensees_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::DNA, Intergenices_ES
dc.subject.meshMedical Subject Headings::Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Biology::Computational Biology::Genomicses_ES
dc.subject.meshMedical Subject Headings::Diseases::Male Urogenital Diseases::Urologic Diseases::Kidney Diseaseses_ES
dc.subject.meshMedical Subject Headings::Diseases::Female Urogenital Diseases and Pregnancy Complications::Female Urogenital Diseases::Urologic Diseases::Kidney Diseaseses_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Biological Factors::Biological Markerses_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeuticses_ES
dc.titleNon-Coding RNAs in Kidney Diseases: The Long and Short of Themes_ES
dc.typereview article
dc.type.hasVersionVoR
dspace.entity.typePublication

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