RT Journal Article
T1 Non-Coding RNAs in Kidney Diseases: The Long and Short of Them
A1 Moreno, Juan Antonio
A1 Hamza, Eya
A1 Guerrero-Hue, Melania
A1 Rayego-Mateos, Sandra
A1 García-Caballero, Cristina
A1 Vallejo-Mudarra, Mercedes
A1 Metzinger, Laurent
A1 Metzinger-Le Meuth, Valérie
K1 Non-coding RNA
K1 MicroRNA
K1 Long non-coding RNA
K1 Chronic kidney disease
K1 Acute kidney disease
K1 IgA nephropathy
K1 Gene regulation
K1 ARN no traducido
K1 MicroARNs
K1 ARN largo no codificante
K1 Insuficiencia renal crónica
K1 Enfermedades renales
K1 Glomerulonefritis por IgA
K1 Regulación de la expresión génica
AB Recent progress in genomic research has highlighted the genome to be much more transcribed than expected. The formerly so-called junk DNA encodes a miscellaneous group of largely unknown RNA transcripts, which contain the long non-coding RNAs (lncRNAs) family. lncRNAs are instrumental in gene regulation. Moreover, understanding their biological roles in the physiopathology of many diseases, including renal, is a new challenge. lncRNAs regulate the effects of microRNAs (miRNA) on mRNA expression. Understanding the complex crosstalk between lncRNA-miRNA-mRNA is one of the main challenges of modern molecular biology. This review aims to summarize the role of lncRNA on kidney diseases, the molecular mechanisms involved, and their function as emerging prognostic biomarkers for both acute and chronic kidney diseases. Finally, we will also outline new therapeutic opportunities to diminish renal injury by targeting lncRNA with antisense oligonucleotides.
PB MDPI
YR 2021
FD 2021-06-04
LK http://hdl.handle.net/10668/4599
UL http://hdl.handle.net/10668/4599
LA en
NO Moreno JA, Hamza E, Guerrero-Hue M, Rayego-Mateos S, García-Caballero C, Vallejo-Mudarra M, et al. Non-Coding RNAs in Kidney Diseases: The Long and Short of Them. Int J Mol Sci. 2021 Jun 4;22(11):6077
DS RISalud
RD Apr 10, 2025