Publication:
A novel human tumoroid 3D model of sustained ACTH-secreting cell cultures to study critically needed therapies for Cushing's disease

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Date

2021-05-13

Authors

Fuentes-Fayos, Antonio C.
Luque, Raul M.

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Elsevier B.V.
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Abstract

The pituitary gland is a master endocrine organ composed of distinct hormone-producing cell types that serve as sensors to integrate central and peripheral signals in order to fine-tune whole-body homeostasis and control multiple physiological functions including growth, reproduction, metabolism, and stress [1]. Classically, pituitary tumours have been considered rare and benign; however, they represent the most common intracranial neoplasms and are often aggressive. Moreover, these tumours are highly heterogeneous, displaying strikingly diverse clinical behaviours that parallel the different pituitary cell subtypes from which they arise [2]. Currently, the in vitro and in vivo pituitary tumour models available are highly limited and, in the case of the corticotroph tumours producing adrenocorticotropic hormone (ACTH), have been mainly restricted to ACTH-secreting murine cell lines (i.e., AtT-20 and AtT-20/D16v-F2) and transgenic/PDX mouse models (e.g., Crh^120/+ and POMC-SV40, among others), respectively [3].

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Medical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Peptide Hormones::Pituitary Hormones::Pituitary Hormones, Anterior::Pro-Opiomelanocortin::Adrenocorticotropic Hormone
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Cytological Techniques::Cell Culture Techniques
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Diseases::Endocrine System Diseases::Pituitary Diseases::Hyperpituitarism::Pituitary ACTH Hypersecretion
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice
Medical Subject Headings::Organisms::Eukaryota::Animals
Medical Subject Headings::Anatomy::Cells::Endocrine Cells::Corticotrophs
Medical Subject Headings::Diseases::Endocrine System Diseases::Pituitary Diseases::Pituitary Neoplasms
Medical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Peptide Hormones::Pituitary Hormones::Pituitary Hormones, Anterior::Pro-Opiomelanocortin
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Cytological Techniques::Cell Culture Techniques::Primary Cell Culture
Medical Subject Headings::Health Care::Health Care Facilities, Manpower, and Services::Health Facilities::Laboratories
Medical Subject Headings::Anatomy::Cells::Cells, Cultured::Cell Line
Medical Subject Headings::Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Reproductive Physiological Processes::Reproduction
Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Physiological Processes::Homeostasis

DeCS Terms

Hipófisis
Neoplasias hipofisarias
Hormona adrenocorticotrópica
Hipersecreción de la hormona adrenocorticotrópica pituitaria (HACT)
Enfermedad de Cushing
Corticotrofos

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Keywords

Corticotroph, Pituitary gland, Pituitary neoplasms, Adrenocorticotropic hormone, Cushing's disease

Citation

Fuentes-Fayos AC, Luque RM. A novel human tumoroid 3D model of sustained ACTH-secreting cell cultures to study critically needed therapies for Cushing's disease. EBioMedicine. 2021 May;67:103368