RT Generic
T1 A novel human tumoroid 3D model of sustained ACTH-secreting cell cultures to study critically needed therapies for Cushing's disease
A1 Fuentes-Fayos, Antonio C.
A1 Luque, Raul M.
K1 Corticotroph
K1 Pituitary gland
K1 Pituitary neoplasms
K1 Adrenocorticotropic hormone
K1 Cushing's disease
AB The pituitary gland is a master endocrine organ composed of distinct hormone-producing cell types that serve as sensors to integrate central and peripheral signals in order to fine-tune whole-body homeostasis and control multiple physiological functions including growth, reproduction, metabolism, and stress [1]. Classically, pituitary tumours have been considered rare and benign; however, they represent the most common intracranial neoplasms and are often aggressive. Moreover, these tumours are highly heterogeneous, displaying strikingly diverse clinical behaviours that parallel the different pituitary cell subtypes from which they arise [2]. Currently, the in vitro and in vivo pituitary tumour models available are highly limited and, in the case of the corticotroph tumours producing adrenocorticotropic hormone (ACTH), have been mainly restricted to ACTH-secreting murine cell lines (i.e., AtT-20 and AtT-20/D16v-F2) and transgenic/PDX mouse models (e.g., Crh^120/+ and POMC-SV40, among others), respectively [3].
PB Elsevier B.V.
YR 2021
FD 2021-05-13
LK http://hdl.handle.net/10668/4401
UL http://hdl.handle.net/10668/4401
LA en
NO Fuentes-Fayos AC, Luque RM. A novel human tumoroid 3D model of sustained ACTH-secreting cell cultures to study critically needed therapies for Cushing's disease. EBioMedicine. 2021 May;67:103368
DS RISalud
RD Jul 3, 2025