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dc.contributor.authorCarrasco-Sánchez, Francisco Javier-
dc.contributor.authorLópez-Carmona, Mª Dolores-
dc.contributor.authorMartínez-Marcos, Francisco Javier-
dc.contributor.authorPérez-Belmonte, Luis M.-
dc.contributor.authorHidalgo-Jiménez, Alicia-
dc.contributor.authorBuonaiuto, Verónica-
dc.contributor.authorSuárez Fernández, Carmen-
dc.contributor.authorFreire Castro, Santiago Jesús-
dc.contributor.authorLuordo, Davide-
dc.contributor.authorPesqueira Fontan, Paula Maria-
dc.contributor.authorBlázquez Encinar, Julio César-
dc.contributor.authorMagallanes Gamboa, Jeffrey Oskar-
dc.contributor.authorde la Peña Fernández, Andrés-
dc.contributor.authorTorres Peña, José David-
dc.contributor.authorFernández Solà, Joaquim-
dc.contributor.authorNapal Lecumberri, Jose Javier-
dc.contributor.authorAmorós Martínez, Francisco-
dc.contributor.authorGuisado Espartero, María Esther-
dc.contributor.authorJorge Ripper, Carlos-
dc.contributor.authorGómez Méndez, Raquel-
dc.contributor.authorVicente López, Natalia-
dc.contributor.authorRomán Bernal, Berta-
dc.contributor.authorRojano Rivero, María Gloria-
dc.contributor.authorRamos Rincón, José Manuel-
dc.contributor.authorGómez Huelgas, Ricardo-
dc.identifier.citationCarrasco-Sánchez FJ, López-Carmona MD, Martínez-Marcos FJ, Pérez-Belmonte LM, Hidalgo-Jiménez A, Buonaiuto V. Admission hyperglycaemia as a predictor of mortality in patients hospitalized with COVID-19 regardless of diabetes status: data from the Spanish SEMI-COVID-19 Registry. Ann Med. 2021 Dec;53(1):103-116.es_ES
dc.identifier.issn0785-3890 (Print)es_ES
dc.identifier.issn1365-2060 (Online)es_ES
dc.description.abstractBackground: Hyperglycaemia has emerged as an important risk factor for death in coronavirus disease 2019 (COVID-19). The aim of this study was to evaluate the association between blood glucose (BG) levels and in-hospital mortality in non-critically patients hospitalized with COVID-19. Methods: This is a retrospective multi-centre study involving patients hospitalized in Spain. Patients were categorized into three groups according to admission BG levels: <140 mg/dL, 140-180 mg/dL and >180 mg/dL. The primary endpoint was all-cause in-hospital mortality. Results: Of the 11,312 patients, only 2128 (18.9%) had diabetes and 2289 (20.4%) died during hospitalization. The in-hospital mortality rates were 15.7% (<140 mg/dL), 33.7% (140-180 mg) and 41.1% (>180 mg/dL), p<.001. The cumulative probability of mortality was significantly higher in patients with hyperglycaemia compared to patients with normoglycaemia (log rank, p<.001), independently of pre-existing diabetes. Hyperglycaemia (after adjusting for age, diabetes, hypertension and other confounding factors) was an independent risk factor of mortality (BG >180 mg/dL: HR 1.50; 95% confidence interval (CI): 1.31-1.73) (BG 140-180 mg/dL; HR 1.48; 95%CI: 1.29-1.70). Hyperglycaemia was also associated with requirement for mechanical ventilation, intensive care unit (ICU) admission and mortality. Conclusions: Admission hyperglycaemia is a strong predictor of all-cause mortality in non-critically hospitalized COVID-19 patients regardless of prior history of diabetes. KEY MESSAGE Admission hyperglycaemia is a stronger and independent risk factor for mortality in COVID-19. Screening for hyperglycaemia, in patients without diabetes, and early treatment of hyperglycaemia should be mandatory in the management of patients hospitalized with COVID-19. Admission hyperglycaemia should not be overlooked in all patients regardless prior history of diabetes.es_ES
dc.description.sponsorshipThe study was completely support by the Spanish Federation of Internal Medicine.es_ES
dc.format.extent16 p.es_ES
dc.publisherTaylor & Francis Group (Informa UK Limited)es_ES
dc.relation.ispartofAnnals of Medicinees_ES
dc.subject.meshMedical Subject Headings::Diseases::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infectionses_ES
dc.subject.meshMedical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Hyperglycemiaes_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Mortalityes_ES
dc.subject.meshMedical Subject Headings::Diseases::Endocrine System Diseases::Diabetes Mellituses_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Clinical Chemistry Tests::Blood Chemical Analysises_ES
dc.subject.meshMedical Subject Headings::Health Care::Environment and Public Health::Public Health::Disease Outbreaks::Epidemics::Pandemicses_ES
dc.subject.meshMedical Subject Headings::Diseases::Virus Diseases::Pneumonia, Virales_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Respiratory Therapy::Respiration, Artificiales_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Registrieses_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Patient Care::Hospitalization::Length of Stayes_ES
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humanses_ES
dc.subject.meshMedical Subject Headings::Geographical Locations::Geographic Locations::Europe::Spaines_ES
dc.titleAdmission hyperglycaemia as a predictor of mortality in patients hospitalized with COVID-19 regardless of diabetes status: data from the Spanish SEMI-COVID-19 Registryes_ES
dc.contributor.groupSEMI-COVID-19 Networkes_ES
dc.rights.accessRightsAcceso abiertoes_ES
dc.contributor.authoraffiliation[Carrasco-Sánchez,FJ; Hidalgo-Jiménez,A] Internal Medicine Department, Juan Ramón Jiménez University Hospital, Huelva, Spain. [López-Carmona,MD; Pérez-Belmonte,LM; Buonaiuto,V; Gómez Huelgas,R] Internal Medicine Department, Málaga Regional University Hospital, Málaga, Spain. [Martínez-Marcos,FJ] Clinical Infectious Disease Unit, Juan Ramón Jiménez University Hospital, Huelva, Spain. [Suárez Fernández,C] Internal Medicine Department, La Princesa University Hospital, Madrid, Spain. [Freire Castro,SJ] Internal Medicine Department, A Coruña University Hospital, A Coruña, Spain. [Luordo,D] Internal Medicine Department, Infanta Cristina University Hospital, Parla, Spain. [Pesqueira Fontan,PM] Internal Medicine Department, Santiago Clinical Hospital, Santiago de Compostela, Santiago, Spain. [Blázquez Encinar,JC] Internal Medicine Department, Torrevieja University Hospital, Torrevieja, Spain. [Magallanes Gamboa,JO] Internal Medicine Department, Nuestra Señora del Prado Hospital, Talavera de la Reina, Spain. [de la Peña Fernández,A] Internal Medicine Department, Son Llàtzer University Hospital, Palma de Mallorca, Spain. [Torres Peña,JD] Lipis and Atherosclerosis Unit, Department of Interna Medicine, Maimonides Biomedical Research Institute of Córdoba (IMIBIC), Reina Sofia University Hospital, University of Córdoba, Spain. [Torres Peña,JD] CIBER Fisiopatologia de la Obesidad y Nutrición (CIBEROBN), Insituto de Salud Carlos III, Córdoba, Spain. [Fernández Solà,J] Internal Medicine Department, Barcelona Clinical Hospital, Barcelona, Spain. [Napal Lecumberri,JJ] Internal Medicine Department, Marqués de Valdecilla University Hospital, Santander, Spain. [Amorós Martínez,F] Internal Medicine Department, Vinalopó University Hospital, Elche, Spain. [Guisado Espartero,ME] Internal Medicine Department, Infanta Margarita Hospital, Cabra, Spain. [Jorge Ripper,C] Internal Medicine Department, Insular de Gran Canaria Hospital, Las Palmas de Gran Canaria, Spain. [Gómez Méndez] Internal Medicine Department, Lucus Augusti University Hospital, Lugo, Spain. [Vicente López,N] Internal Medicine Department, Sureste University Hospital, Arganda del Rey, Spain. [Román Bernal,B] Internal Medicine Department, Doctor José Molina Orosa Hospital, Arrecife, Spain. [Rojano Rivero,MG] Internal Medicine Department, Infanta Elena Hospital, Huelva Hospital, Huelva, Spain. [Ramos Rincón,JM] Internal Medicine Department, Alicante General University Hospital, Alicante, Spain.es_ES
dc.type.subtypeArtículo originales_ES
Appears in Collections:01- Artículos - AGS Sur de Córdoba
01- Artículos - Hospital Infanta Elena
01- Artículos - Hospital Juan Ramón Jiménez
01- Artículos - Hospital Regional de Málaga
01- Artículos - IMIBIC. Instituto Maimónides de Investigación Biomédica de Córdoba

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