%0 Journal Article
%A Carrasco-Sánchez, Francisco Javier
%A López-Carmona, Mª Dolores
%A Martínez-Marcos, Francisco Javier
%A Pérez-Belmonte, Luis M.
%A Hidalgo-Jiménez, Alicia
%A Buonaiuto, Verónica
%A Suárez Fernández, Carmen
%A Freire Castro, Santiago Jesús
%A Luordo, Davide
%A Pesqueira Fontan, Paula Maria
%A Blázquez Encinar, Julio César
%A Magallanes Gamboa, Jeffrey Oskar
%A de la Peña Fernández, Andrés
%A Torres Peña, José David
%A Fernández Solà, Joaquim
%A Napal Lecumberri, Jose Javier
%A Amorós Martínez, Francisco
%A Guisado Espartero, María Esther
%A Jorge Ripper, Carlos
%A Gómez Méndez, Raquel
%A Vicente López, Natalia
%A Román Bernal, Berta
%A Rojano Rivero, María Gloria
%A Ramos Rincón, José Manuel
%A Gómez Huelgas, Ricardo
%T Admission hyperglycaemia as a predictor of mortality in patients hospitalized with COVID-19 regardless of diabetes status: data from the Spanish SEMI-COVID-19 Registry
%D 2020
%@ 0785-3890
%U http://hdl.handle.net/10668/3212
%X Background: Hyperglycaemia has emerged as an important risk factor for death in coronavirus disease 2019 (COVID-19). The aim of this study was to evaluate the association between blood glucose (BG) levels and in-hospital mortality in non-critically patients hospitalized with COVID-19.Methods: This is a retrospective multi-centre study involving patients hospitalized in Spain. Patients were categorized into three groups according to admission BG levels: <140 mg/dL, 140-180 mg/dL and >180 mg/dL. The primary endpoint was all-cause in-hospital mortality.Results: Of the 11,312 patients, only 2128 (18.9%) had diabetes and 2289 (20.4%) died during hospitalization. The in-hospital mortality rates were 15.7% (<140 mg/dL), 33.7% (140-180 mg) and 41.1% (>180 mg/dL), p<.001. The cumulative probability of mortality was significantly higher in patients with hyperglycaemia compared to patients with normoglycaemia (log rank, p<.001), independently of pre-existing diabetes. Hyperglycaemia (after adjusting for age, diabetes, hypertension and other confounding factors) was an independent risk factor of mortality (BG >180 mg/dL: HR 1.50; 95% confidence interval (CI): 1.31-1.73) (BG 140-180 mg/dL; HR 1.48; 95%CI: 1.29-1.70). Hyperglycaemia was also associated with requirement for mechanical ventilation, intensive care unit (ICU) admission and mortality.Conclusions: Admission hyperglycaemia is a strong predictor of all-cause mortality in non-critically hospitalized COVID-19 patients regardless of prior history of diabetes. KEY MESSAGE Admission hyperglycaemia is a stronger and independent risk factor for mortality in COVID-19. Screening for hyperglycaemia, in patients without diabetes, and early treatment of hyperglycaemia should be mandatory in the management of patients hospitalized with COVID-19. Admission hyperglycaemia should not be overlooked in all patients regardless prior history of diabetes.
%K SARS-CoV-2
%K COVID-19
%K Hyperglycaemia
%K Mortality
%K Diabetes
%K Hyperglycemia
%K Hiperglucemia
%K Mortalidad
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