Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/3212
Title: Admission hyperglycaemia as a predictor of mortality in patients hospitalized with COVID-19 regardless of diabetes status: data from the Spanish SEMI-COVID-19 Registry
Authors: Carrasco-Sánchez, Francisco Javier
López-Carmona, Mª Dolores
Martínez-Marcos, Francisco Javier
Pérez-Belmonte, Luis M.
Hidalgo-Jiménez, Alicia
Buonaiuto, Verónica
Suárez Fernández, Carmen
Freire Castro, Santiago Jesús
Luordo, Davide
Pesqueira Fontan, Paula Maria
Blázquez Encinar, Julio César
Magallanes Gamboa, Jeffrey Oskar
de la Peña Fernández, Andrés
Torres Peña, José David
Fernández Solà, Joaquim
Napal Lecumberri, Jose Javier
Amorós Martínez, Francisco
Guisado Espartero, María Esther
Jorge Ripper, Carlos
Gómez Méndez, Raquel
Vicente López, Natalia
Román Bernal, Berta
Rojano Rivero, María Gloria
Ramos Rincón, José Manuel
Gómez Huelgas, Ricardo
metadata.dc.contributor.authoraffiliation: [Carrasco-Sánchez,FJ; Hidalgo-Jiménez,A] Internal Medicine Department, Juan Ramón Jiménez University Hospital, Huelva, Spain. [López-Carmona,MD; Pérez-Belmonte,LM; Buonaiuto,V; Gómez Huelgas,R] Internal Medicine Department, Málaga Regional University Hospital, Málaga, Spain. [Martínez-Marcos,FJ] Clinical Infectious Disease Unit, Juan Ramón Jiménez University Hospital, Huelva, Spain. [Suárez Fernández,C] Internal Medicine Department, La Princesa University Hospital, Madrid, Spain. [Freire Castro,SJ] Internal Medicine Department, A Coruña University Hospital, A Coruña, Spain. [Luordo,D] Internal Medicine Department, Infanta Cristina University Hospital, Parla, Spain. [Pesqueira Fontan,PM] Internal Medicine Department, Santiago Clinical Hospital, Santiago de Compostela, Santiago, Spain. [Blázquez Encinar,JC] Internal Medicine Department, Torrevieja University Hospital, Torrevieja, Spain. [Magallanes Gamboa,JO] Internal Medicine Department, Nuestra Señora del Prado Hospital, Talavera de la Reina, Spain. [de la Peña Fernández,A] Internal Medicine Department, Son Llàtzer University Hospital, Palma de Mallorca, Spain. [Torres Peña,JD] Lipis and Atherosclerosis Unit, Department of Interna Medicine, Maimonides Biomedical Research Institute of Córdoba (IMIBIC), Reina Sofia University Hospital, University of Córdoba, Spain. [Torres Peña,JD] CIBER Fisiopatologia de la Obesidad y Nutrición (CIBEROBN), Insituto de Salud Carlos III, Córdoba, Spain. [Fernández Solà,J] Internal Medicine Department, Barcelona Clinical Hospital, Barcelona, Spain. [Napal Lecumberri,JJ] Internal Medicine Department, Marqués de Valdecilla University Hospital, Santander, Spain. [Amorós Martínez,F] Internal Medicine Department, Vinalopó University Hospital, Elche, Spain. [Guisado Espartero,ME] Internal Medicine Department, Infanta Margarita Hospital, Cabra, Spain. [Jorge Ripper,C] Internal Medicine Department, Insular de Gran Canaria Hospital, Las Palmas de Gran Canaria, Spain. [Gómez Méndez] Internal Medicine Department, Lucus Augusti University Hospital, Lugo, Spain. [Vicente López,N] Internal Medicine Department, Sureste University Hospital, Arganda del Rey, Spain. [Román Bernal,B] Internal Medicine Department, Doctor José Molina Orosa Hospital, Arrecife, Spain. [Rojano Rivero,MG] Internal Medicine Department, Infanta Elena Hospital, Huelva Hospital, Huelva, Spain. [Ramos Rincón,JM] Internal Medicine Department, Alicante General University Hospital, Alicante, Spain.
metadata.dc.contributor.group: SEMI-COVID-19 Network
Keywords: SARS-CoV-2;COVID-19;Hyperglycaemia;Mortality;Diabetes;Hyperglycemia;Hiperglucemia;Mortalidad
metadata.dc.subject.mesh: Medical Subject Headings::Diseases::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections
Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Hyperglycemia
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Mortality
Medical Subject Headings::Diseases::Endocrine System Diseases::Diabetes Mellitus
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Clinical Chemistry Tests::Blood Chemical Analysis
Medical Subject Headings::Health Care::Environment and Public Health::Public Health::Disease Outbreaks::Epidemics::Pandemics
Medical Subject Headings::Diseases::Virus Diseases::Pneumonia, Viral
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Respiratory Therapy::Respiration, Artificial
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Registries
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Patient Care::Hospitalization::Length of Stay
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Geographical Locations::Geographic Locations::Europe::Spain
Issue Date: 4-Nov-2020
Publisher: Taylor & Francis Group (Informa UK Limited)
Citation: Carrasco-Sánchez FJ, López-Carmona MD, Martínez-Marcos FJ, Pérez-Belmonte LM, Hidalgo-Jiménez A, Buonaiuto V. Admission hyperglycaemia as a predictor of mortality in patients hospitalized with COVID-19 regardless of diabetes status: data from the Spanish SEMI-COVID-19 Registry. Ann Med. 2021 Dec;53(1):103-116.
Abstract: Background: Hyperglycaemia has emerged as an important risk factor for death in coronavirus disease 2019 (COVID-19). The aim of this study was to evaluate the association between blood glucose (BG) levels and in-hospital mortality in non-critically patients hospitalized with COVID-19. Methods: This is a retrospective multi-centre study involving patients hospitalized in Spain. Patients were categorized into three groups according to admission BG levels: <140 mg/dL, 140-180 mg/dL and >180 mg/dL. The primary endpoint was all-cause in-hospital mortality. Results: Of the 11,312 patients, only 2128 (18.9%) had diabetes and 2289 (20.4%) died during hospitalization. The in-hospital mortality rates were 15.7% (<140 mg/dL), 33.7% (140-180 mg) and 41.1% (>180 mg/dL), p<.001. The cumulative probability of mortality was significantly higher in patients with hyperglycaemia compared to patients with normoglycaemia (log rank, p<.001), independently of pre-existing diabetes. Hyperglycaemia (after adjusting for age, diabetes, hypertension and other confounding factors) was an independent risk factor of mortality (BG >180 mg/dL: HR 1.50; 95% confidence interval (CI): 1.31-1.73) (BG 140-180 mg/dL; HR 1.48; 95%CI: 1.29-1.70). Hyperglycaemia was also associated with requirement for mechanical ventilation, intensive care unit (ICU) admission and mortality. Conclusions: Admission hyperglycaemia is a strong predictor of all-cause mortality in non-critically hospitalized COVID-19 patients regardless of prior history of diabetes. KEY MESSAGE Admission hyperglycaemia is a stronger and independent risk factor for mortality in COVID-19. Screening for hyperglycaemia, in patients without diabetes, and early treatment of hyperglycaemia should be mandatory in the management of patients hospitalized with COVID-19. Admission hyperglycaemia should not be overlooked in all patients regardless prior history of diabetes.
URI: https://www.repositoriosalud.es/10668/10668/3212
metadata.dc.relation.publisherversion: https://www.tandfonline.com/doi/abs/10.1080/07853890.2020.1836566
metadata.dc.identifier.doi: 10.1080/07853890.2020.1836566
ISSN: 0785-3890 (Print)
1365-2060 (Online)
Appears in Collections:01- Artículos - AGS Sur de Córdoba
01- Artículos - Hospital Infanta Elena
01- Artículos - Hospital Juan Ramón Jiménez
01- Artículos - Hospital Regional de Málaga
01- Artículos - IMIBIC. Instituto Maimónides de Investigación Biomédica de Córdoba

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