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Title: A Collaborative Analysis of Individual Participant Data from 19 Prospective Studies Assesses Circulating Vitamin D and Prostate Cancer Risk.
Authors: Travis, Ruth C
Perez-Cornago, Aurora
Appleby, Paul N
Albanes, Demetrius
Joshu, Corinne E
Lutsey, Pamela L
Mondul, Alison M
Platz, Elizabeth A
Weinstein, Stephanie J
Layne, Tracy M
Helzlsouer, Kathy J
Visvanathan, Kala
Palli, Domenico
Peeters, Petra H
Bueno-de-Mesquita, Bas
Trichopoulou, Antonia
Gunter, Marc J
Tsilidis, Konstantinos K
Sánchez, Maria-Jose
Olsen, Anja
Brenner, Hermann
Schöttker, Ben
Perna, Laura
Holleczek, Bernd
Knekt, Paul
Rissanen, Harri
Yeap, Bu B
Flicker, Leon
Almeida, Osvaldo P
Wong, Yuen Yee Elizabeth
Chan, June M
Giovannucci, Edward L
Stampfer, Meir J
Ursin, Giske
Gislefoss, Randi E
Bjørge, Tone
Meyer, Haakon E
Blomhoff, Rune
Tsugane, Shoichiro
Sawada, Norie
English, Dallas R
Eyles, Darryl W
Heath, Alicia K
Williamson, Elizabeth J
Manjer, Jonas
Malm, Johan
Almquist, Martin
Marchand, Loic Le
Haiman, Christopher A
Wilkens, Lynne R
Schenk, Jeannette M
Tangen, Cathy M
Black, Amanda
Cook, Michael B
Huang, Wen-Yi
Ziegler, Regina G
Martin, Richard M
Hamdy, Freddie C
Donovan, Jenny L
Neal, David E
Touvier, Mathilde
Hercberg, Serge
Galan, Pilar
Deschasaux, Mélanie
Key, Timothy J
Allen, Naomi E
metadata.dc.subject.mesh: Aged
Case-Control Studies
Cross-Sectional Studies
Middle Aged
Odds Ratio
Prospective Studies
Prostatic Neoplasms
Risk Assessment
Risk Factors
Vitamin D
Issue Date: 13-Nov-2018
Abstract: Previous prospective studies assessing the relationship between circulating concentrations of vitamin D and prostate cancer risk have shown inconclusive results, particularly for risk of aggressive disease. In this study, we examine the association between prediagnostic concentrations of 25-hydroxyvitamin D [25(OH)D] and 1,25-dihydroxyvitamin D [1,25(OH)2D] and the risk of prostate cancer overall and by tumor characteristics. Principal investigators of 19 prospective studies provided individual participant data on circulating 25(OH)D and 1,25(OH)2D for up to 13,462 men with incident prostate cancer and 20,261 control participants. ORs for prostate cancer by study-specific fifths of season-standardized vitamin D concentration were estimated using multivariable-adjusted conditional logistic regression. 25(OH)D concentration was positively associated with risk for total prostate cancer (multivariable-adjusted OR comparing highest vs. lowest study-specific fifth was 1.22; 95% confidence interval, 1.13-1.31; P trend
metadata.dc.identifier.doi: 10.1158/0008-5472.CAN-18-2318
Appears in Collections:Producción 2020

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