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http://hdl.handle.net/10668/13183| Title: | A Collaborative Analysis of Individual Participant Data from 19 Prospective Studies Assesses Circulating Vitamin D and Prostate Cancer Risk. |
| Authors: | Travis, Ruth C Perez-Cornago, Aurora Appleby, Paul N Albanes, Demetrius Joshu, Corinne E Lutsey, Pamela L Mondul, Alison M Platz, Elizabeth A Weinstein, Stephanie J Layne, Tracy M Helzlsouer, Kathy J Visvanathan, Kala Palli, Domenico Peeters, Petra H Bueno-de-Mesquita, Bas Trichopoulou, Antonia Gunter, Marc J Tsilidis, Konstantinos K Sánchez, Maria-Jose Olsen, Anja Brenner, Hermann Schöttker, Ben Perna, Laura Holleczek, Bernd Knekt, Paul Rissanen, Harri Yeap, Bu B Flicker, Leon Almeida, Osvaldo P Wong, Yuen Yee Elizabeth Chan, June M Giovannucci, Edward L Stampfer, Meir J Ursin, Giske Gislefoss, Randi E Bjørge, Tone Meyer, Haakon E Blomhoff, Rune Tsugane, Shoichiro Sawada, Norie English, Dallas R Eyles, Darryl W Heath, Alicia K Williamson, Elizabeth J Manjer, Jonas Malm, Johan Almquist, Martin Marchand, Loic Le Haiman, Christopher A Wilkens, Lynne R Schenk, Jeannette M Tangen, Cathy M Black, Amanda Cook, Michael B Huang, Wen-Yi Ziegler, Regina G Martin, Richard M Hamdy, Freddie C Donovan, Jenny L Neal, David E Touvier, Mathilde Hercberg, Serge Galan, Pilar Deschasaux, Mélanie Key, Timothy J Allen, Naomi E |
| metadata.dc.subject.mesh: | Aged Case-Control Studies Cross-Sectional Studies Humans Male Middle Aged Odds Ratio Prospective Studies Prostatic Neoplasms Risk Assessment Risk Factors Vitamin D |
| Issue Date: | 13-Nov-2018 |
| Abstract: | Previous prospective studies assessing the relationship between circulating concentrations of vitamin D and prostate cancer risk have shown inconclusive results, particularly for risk of aggressive disease. In this study, we examine the association between prediagnostic concentrations of 25-hydroxyvitamin D [25(OH)D] and 1,25-dihydroxyvitamin D [1,25(OH)2D] and the risk of prostate cancer overall and by tumor characteristics. Principal investigators of 19 prospective studies provided individual participant data on circulating 25(OH)D and 1,25(OH)2D for up to 13,462 men with incident prostate cancer and 20,261 control participants. ORs for prostate cancer by study-specific fifths of season-standardized vitamin D concentration were estimated using multivariable-adjusted conditional logistic regression. 25(OH)D concentration was positively associated with risk for total prostate cancer (multivariable-adjusted OR comparing highest vs. lowest study-specific fifth was 1.22; 95% confidence interval, 1.13-1.31; P trend |
| URI: | http://hdl.handle.net/10668/13183 |
| metadata.dc.identifier.doi: | 10.1158/0008-5472.CAN-18-2318 |
| Appears in Collections: | Producción 2020 |
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