Publication:
A Collaborative Analysis of Individual Participant Data from 19 Prospective Studies Assesses Circulating Vitamin D and Prostate Cancer Risk.

dc.contributor.authorTravis, Ruth C
dc.contributor.authorPerez-Cornago, Aurora
dc.contributor.authorAppleby, Paul N
dc.contributor.authorAlbanes, Demetrius
dc.contributor.authorJoshu, Corinne E
dc.contributor.authorLutsey, Pamela L
dc.contributor.authorMondul, Alison M
dc.contributor.authorPlatz, Elizabeth A
dc.contributor.authorWeinstein, Stephanie J
dc.contributor.authorLayne, Tracy M
dc.contributor.authorHelzlsouer, Kathy J
dc.contributor.authorVisvanathan, Kala
dc.contributor.authorPalli, Domenico
dc.contributor.authorPeeters, Petra H
dc.contributor.authorBueno-de-Mesquita, Bas
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorGunter, Marc J
dc.contributor.authorTsilidis, Konstantinos K
dc.contributor.authorSánchez, Maria-Jose
dc.contributor.authorOlsen, Anja
dc.contributor.authorBrenner, Hermann
dc.contributor.authorSchöttker, Ben
dc.contributor.authorPerna, Laura
dc.contributor.authorHolleczek, Bernd
dc.contributor.authorKnekt, Paul
dc.contributor.authorRissanen, Harri
dc.contributor.authorYeap, Bu B
dc.contributor.authorFlicker, Leon
dc.contributor.authorAlmeida, Osvaldo P
dc.contributor.authorWong, Yuen Yee Elizabeth
dc.contributor.authorChan, June M
dc.contributor.authorGiovannucci, Edward L
dc.contributor.authorStampfer, Meir J
dc.contributor.authorUrsin, Giske
dc.contributor.authorGislefoss, Randi E
dc.contributor.authorBjørge, Tone
dc.contributor.authorMeyer, Haakon E
dc.contributor.authorBlomhoff, Rune
dc.contributor.authorTsugane, Shoichiro
dc.contributor.authorSawada, Norie
dc.contributor.authorEnglish, Dallas R
dc.contributor.authorEyles, Darryl W
dc.contributor.authorHeath, Alicia K
dc.contributor.authorWilliamson, Elizabeth J
dc.contributor.authorManjer, Jonas
dc.contributor.authorMalm, Johan
dc.contributor.authorAlmquist, Martin
dc.contributor.authorMarchand, Loic Le
dc.contributor.authorHaiman, Christopher A
dc.contributor.authorWilkens, Lynne R
dc.contributor.authorSchenk, Jeannette M
dc.contributor.authorTangen, Cathy M
dc.contributor.authorBlack, Amanda
dc.contributor.authorCook, Michael B
dc.contributor.authorHuang, Wen-Yi
dc.contributor.authorZiegler, Regina G
dc.contributor.authorMartin, Richard M
dc.contributor.authorHamdy, Freddie C
dc.contributor.authorDonovan, Jenny L
dc.contributor.authorNeal, David E
dc.contributor.authorTouvier, Mathilde
dc.contributor.authorHercberg, Serge
dc.contributor.authorGalan, Pilar
dc.contributor.authorDeschasaux, Mélanie
dc.contributor.authorKey, Timothy J
dc.contributor.authorAllen, Naomi E
dc.date.accessioned2023-01-25T10:24:24Z
dc.date.available2023-01-25T10:24:24Z
dc.date.issued2018-11-13
dc.description.abstractPrevious prospective studies assessing the relationship between circulating concentrations of vitamin D and prostate cancer risk have shown inconclusive results, particularly for risk of aggressive disease. In this study, we examine the association between prediagnostic concentrations of 25-hydroxyvitamin D [25(OH)D] and 1,25-dihydroxyvitamin D [1,25(OH)2D] and the risk of prostate cancer overall and by tumor characteristics. Principal investigators of 19 prospective studies provided individual participant data on circulating 25(OH)D and 1,25(OH)2D for up to 13,462 men with incident prostate cancer and 20,261 control participants. ORs for prostate cancer by study-specific fifths of season-standardized vitamin D concentration were estimated using multivariable-adjusted conditional logistic regression. 25(OH)D concentration was positively associated with risk for total prostate cancer (multivariable-adjusted OR comparing highest vs. lowest study-specific fifth was 1.22; 95% confidence interval, 1.13-1.31; P trend
dc.identifier.doi10.1158/0008-5472.CAN-18-2318
dc.identifier.essn1538-7445
dc.identifier.pmcPMC6330070
dc.identifier.pmid30425058
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330070/pdf
dc.identifier.unpaywallURLhttps://europepmc.org/articles/pmc6330070?pdf=render
dc.identifier.urihttp://hdl.handle.net/10668/13183
dc.issue.number1
dc.journal.titleCancer research
dc.journal.titleabbreviationCancer Res
dc.language.isoen
dc.organizationHospital Universitario San Cecilio
dc.page.number274-285
dc.pubmedtypeJournal Article
dc.pubmedtypeMulticenter Study
dc.pubmedtypeResearch Support, Non-U.S. Gov't
dc.rights.accessRightsopen access
dc.subject.meshAged
dc.subject.meshCase-Control Studies
dc.subject.meshCross-Sectional Studies
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshOdds Ratio
dc.subject.meshProspective Studies
dc.subject.meshProstatic Neoplasms
dc.subject.meshRisk Assessment
dc.subject.meshRisk Factors
dc.subject.meshVitamin D
dc.titleA Collaborative Analysis of Individual Participant Data from 19 Prospective Studies Assesses Circulating Vitamin D and Prostate Cancer Risk.
dc.typeresearch article
dc.type.hasVersionAM
dc.volume.number79
dspace.entity.typePublication

Files