RT Journal Article T1 A Collaborative Analysis of Individual Participant Data from 19 Prospective Studies Assesses Circulating Vitamin D and Prostate Cancer Risk. A1 Travis, Ruth C A1 Perez-Cornago, Aurora A1 Appleby, Paul N A1 Albanes, Demetrius A1 Joshu, Corinne E A1 Lutsey, Pamela L A1 Mondul, Alison M A1 Platz, Elizabeth A A1 Weinstein, Stephanie J A1 Layne, Tracy M A1 Helzlsouer, Kathy J A1 Visvanathan, Kala A1 Palli, Domenico A1 Peeters, Petra H A1 Bueno-de-Mesquita, Bas A1 Trichopoulou, Antonia A1 Gunter, Marc J A1 Tsilidis, Konstantinos K A1 Sánchez, Maria-Jose A1 Olsen, Anja A1 Brenner, Hermann A1 Schöttker, Ben A1 Perna, Laura A1 Holleczek, Bernd A1 Knekt, Paul A1 Rissanen, Harri A1 Yeap, Bu B A1 Flicker, Leon A1 Almeida, Osvaldo P A1 Wong, Yuen Yee Elizabeth A1 Chan, June M A1 Giovannucci, Edward L A1 Stampfer, Meir J A1 Ursin, Giske A1 Gislefoss, Randi E A1 Bjørge, Tone A1 Meyer, Haakon E A1 Blomhoff, Rune A1 Tsugane, Shoichiro A1 Sawada, Norie A1 English, Dallas R A1 Eyles, Darryl W A1 Heath, Alicia K A1 Williamson, Elizabeth J A1 Manjer, Jonas A1 Malm, Johan A1 Almquist, Martin A1 Marchand, Loic Le A1 Haiman, Christopher A A1 Wilkens, Lynne R A1 Schenk, Jeannette M A1 Tangen, Cathy M A1 Black, Amanda A1 Cook, Michael B A1 Huang, Wen-Yi A1 Ziegler, Regina G A1 Martin, Richard M A1 Hamdy, Freddie C A1 Donovan, Jenny L A1 Neal, David E A1 Touvier, Mathilde A1 Hercberg, Serge A1 Galan, Pilar A1 Deschasaux, Mélanie A1 Key, Timothy J A1 Allen, Naomi E AB Previous prospective studies assessing the relationship between circulating concentrations of vitamin D and prostate cancer risk have shown inconclusive results, particularly for risk of aggressive disease. In this study, we examine the association between prediagnostic concentrations of 25-hydroxyvitamin D [25(OH)D] and 1,25-dihydroxyvitamin D [1,25(OH)2D] and the risk of prostate cancer overall and by tumor characteristics. Principal investigators of 19 prospective studies provided individual participant data on circulating 25(OH)D and 1,25(OH)2D for up to 13,462 men with incident prostate cancer and 20,261 control participants. ORs for prostate cancer by study-specific fifths of season-standardized vitamin D concentration were estimated using multivariable-adjusted conditional logistic regression. 25(OH)D concentration was positively associated with risk for total prostate cancer (multivariable-adjusted OR comparing highest vs. lowest study-specific fifth was 1.22; 95% confidence interval, 1.13-1.31; P trend YR 2018 FD 2018-11-13 LK http://hdl.handle.net/10668/13183 UL http://hdl.handle.net/10668/13183 LA en DS RISalud RD May 12, 2025