Publication: An ex vivo native environment precision medicine test shows high clinical correlation with responses to first line acute myeloid leukemia treatment
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Identifiers
Date
2016-06
Authors
Montesinos, P
Ballesteros, J
Martinez Cuadron, D
Martinez Lopez, J
Serrano, J
Perez de Oteyza, J
Fernandez, P
Rodriguez Macias, G
Vidriales, B
Herrera, P
Advisors
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Volume Title
Publisher
Ferrata Storti Foundation
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Abstract
This novel test is able to predict the clinical response to Ida+Ara-C induction with overall correlation and predictive values of 80%, higher than ever achieved. Considering this result and current clinical response
rate of 66.7% (70% in this study), clear clinical benefits can be achieved with
the use of the test. Adding the cytogenetic risk profile further increase the correlation
to 90%. Thus this novel test may be valuable information to guide 1st line patient therapy
Description
MeSH Terms
Medical Subject Headings::Named Groups::Persons::Age Groups::Adult
Medical Subject Headings::Anatomy::Hemic and Immune Systems::Immune System::Bone Marrow
Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleosides::Pyrimidine Nucleosides::Cytidine
Medical Subject Headings::Phenomena and Processes::Biological Phenomena::Ecological and Environmental Phenomena::Environment
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Hydrocarbons::Hydrocarbons, Cyclic::Hydrocarbons, Aromatic::Polycyclic Hydrocarbons, Aromatic::Naphthacenes::Anthracyclines::Daunorubicin::Idarubicin
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Drug Therapy::Induction Chemotherapy
Medical Subject Headings::Health Care::Health Care Facilities, Manpower, and Services::Maintenance
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Remission Induction
Medical Subject Headings::Anatomy::Hemic and Immune Systems::Immune System::Bone Marrow
Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleosides::Pyrimidine Nucleosides::Cytidine
Medical Subject Headings::Phenomena and Processes::Biological Phenomena::Ecological and Environmental Phenomena::Environment
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Hydrocarbons::Hydrocarbons, Cyclic::Hydrocarbons, Aromatic::Polycyclic Hydrocarbons, Aromatic::Naphthacenes::Anthracyclines::Daunorubicin::Idarubicin
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Drug Therapy::Induction Chemotherapy
Medical Subject Headings::Health Care::Health Care Facilities, Manpower, and Services::Maintenance
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Remission Induction
DeCS Terms
CIE Terms
Keywords
Adulto, Médula ósea, Citarabina, Ambiente, Humanos, Idarrubicina, Quimioterapia de inducción, Mantenimiento
Citation
Montesinos P, Ballesteros J, Martinez Cuadron D. Martinez Lopez J, Serrano J, Perez de Oteyza J et al. An ex vivo native environment precision medicine test shows high clinical correlation with responses to first line acute myeloid leukemia treatment. Haematologica. 2016; 101 (s1) P569