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An ex vivo native environment precision medicine test shows high clinical correlation with responses to first line acute myeloid leukemia treatment

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dc.contributor.authorMontesinos, P
dc.contributor.authorBallesteros, J
dc.contributor.authorMartinez Cuadron, D
dc.contributor.authorMartinez Lopez, J
dc.contributor.authorSerrano, J
dc.contributor.authorPerez de Oteyza, J
dc.contributor.authorFernandez, P
dc.contributor.authorRodriguez Macias, G
dc.contributor.authorVidriales, B
dc.contributor.authorHerrera, P
dc.contributor.authorTormo, M
dc.contributor.authorBergua, J
dc.contributor.authorGarcia, R
dc.contributor.authorVives, S
dc.contributor.authorFernandez, MA
dc.contributor.authorLavilla, E
dc.contributor.authorJimenez, S
dc.contributor.authorPerez Simon, JA
dc.contributor.authorSimiele, A
dc.contributor.authorGonzalez, A
dc.contributor.authorGonzalez, B
dc.contributor.authorBurgaleta, C
dc.contributor.authorLopez, JA
dc.contributor.authorBethancourt, C
dc.contributor.authorBautista, G
dc.contributor.authorAlonso, A
dc.contributor.authorColorado, M
dc.contributor.authorSierra, J
dc.contributor.authorNavas, B
dc.contributor.authorHernandez Rivas, JA
dc.contributor.authorVera, JA
dc.contributor.authorAmador, L
dc.contributor.authorCordoba, R
dc.contributor.authorde la Fuente, A
dc.contributor.authorRamos, F
dc.contributor.authorCervero, CJ
dc.contributor.authorRayon, C
dc.contributor.authorSalamero, O
dc.contributor.authorMarti, E
dc.contributor.authorLoez, A
dc.contributor.authorOlave, T
dc.contributor.authorGaspar, M
dc.contributor.authorGorrochategui, J
dc.contributor.authorRojas, JL
dc.contributor.authorGomez, C
dc.contributor.authorHernandez, P
dc.contributor.authorRobles, A
dc.contributor.authorOrtega, I
dc.contributor.authorVilloria, J
dc.contributor.authorMoscardo, F
dc.contributor.authorTroconiz, I
dc.contributor.authorSanz, MA
dc.contributor.authoraffiliation[Montesinos,P; Martinez Cuadron,D; Moscardo,F; Sanz,MA] Hospital Universitari i Politecnic La Fe, Valencia. [Ballesteros,J; Gaspar,G; Gorrochategui,J; Rojas, JL; Gomez,C; Hernandez,P; Robles,A] Vivia Biotech, Tres Cantos. [Martinez Lopez, J] Hospital Universitario 12 de Octubre, Madrid. [Serrano,J] Hospital Universitario Reina Sofia, Cordoba. [Perez de Oteyza,J] Hospital Universitario San Chinarro, Madrid. [Fernandez,P] Hospital General Universitario de Alicante, Alicante. [Rodriguez Macias,G] Hospital Gregorio Marañon, Madrid. [Vidriales,B] Hospital Clinico Universitario de Salamanca, Salamanca. [Herrera,P] Hospital Universitario Ramon y Cajal, Madrid. [Tormo,M] Hospital Clinico Universitario de Valencia, Valencia.[Bergua,J ]Hospital San Pedro de Alcantara, Caceres. [Garcia,R] Hospital Universitario de Castellon, Castellon. [Vives,S] Hospital Universitari Germans Trias i Pujol, Badalona. [Fernandez,MA] Hopsital Xeral Cies, Vigo. [Lavilla,E] Hospital Lucus Augusti, Lugo. [Jimenez,S] Hospital Universitario de Gran Canaria Doctor Negrin, Las Palmas de Gran Canaria. [Perez Simon,JA] Hospital Universitario Virgen del Rocio, Sevilla. [Simiele,A] Hospital Povisa, Vigo. [Gonzalez,A] Hospital Universitario Clinico San Carlos, Madrid. [Gonzalez,B] Hospital Universitario de Canarias, La Laguna. [Burgaleta,C] Hospital Universitario Principe de Asturias, Alcala de Henares. [Lopez, JA] Complejo Hospitalario de Jaen, Jaen. [Bethancourt,C] Hospital Carlos Haya, Malaga. [Bautista,G] Hospital Universitario Puerta de Hierro, Majadahonda. [Alonso,A] Hospital Quiron, Madrid. [Colorado,M] Hospital Universitario Marques de Valdecilla, Santander. [Sierra,J] Hospital de la Santa Creu i Sant Pau, Barcelona. [Navas,B] Hospital Moncloa. [Hernandez Rivas, JA] Hospital Infanta Leonor, Madrid. [Vera,JA] Hospital Universitario Virgen Macarena, Sevilla. [Amador,L] Hospital Montecelo, Pontevedra. [Cordoba,R] Hospital Fundacion JImenez Diaz. [de la Fuente,A] MD Anderson Medical Center, Madrid. [Ramos,F] Hospital Universitario de Leon, Leon. [Cervero,CJ] Hospital Virgen de la Luz, Cuenca. [Rayon,C] Hospital Universitario Central de Asturias, Oviedo. [Salamero,O] Hospital Universitari Vall d’Hebron, Barcelona. [Marti,E] Hospital de Manises, Manises. [Loez,A] Hospital Arnau de Vilanova, Valencia. [Olave,T] Hospital Clinico Universitario LOzano Blesa, Zaragoza. [Ortega,I] Universidad del Pais Vasco, Bilbao. [Villoria,J] Medicxact, Madrid. [Troconiz,I] Universidad de Navarra, Pamplona, Spain.es
dc.date.accessioned2016-10-03T11:14:31Z
dc.date.available2016-10-03T11:14:31Z
dc.date.issued2016-06
dc.description.abstractThis novel test is able to predict the clinical response to Ida+Ara-C induction with overall correlation and predictive values of 80%, higher than ever achieved. Considering this result and current clinical response rate of 66.7% (70% in this study), clear clinical benefits can be achieved with the use of the test. Adding the cytogenetic risk profile further increase the correlation to 90%. Thus this novel test may be valuable information to guide 1st line patient therapyes
dc.description.versionNoes
dc.identifier.citationMontesinos P, Ballesteros J, Martinez Cuadron D. Martinez Lopez J, Serrano J, Perez de Oteyza J et al. An ex vivo native environment precision medicine test shows high clinical correlation with responses to first line acute myeloid leukemia treatment. Haematologica. 2016; 101 (s1) P569es
dc.identifier.essn1592-8721
dc.identifier.issn0390-6078
dc.identifier.urihttp://hdl.handle.net/10668/2442
dc.journal.titleHaematologica
dc.language.isoen
dc.publisherFerrata Storti Foundationes
dc.relation.publisherversionhttp://www.haematologica.org/content/101/s1es
dc.rights.accessRightsopen access
dc.subjectAdultoes
dc.subjectMédula óseaes
dc.subjectCitarabinaes
dc.subjectAmbientees
dc.subjectHumanoses
dc.subjectIdarrubicinaes
dc.subjectQuimioterapia de inducciónes
dc.subjectMantenimientoes
dc.subject.meshMedical Subject Headings::Named Groups::Persons::Age Groups::Adultes
dc.subject.meshMedical Subject Headings::Anatomy::Hemic and Immune Systems::Immune System::Bone Marrowes
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleosides::Pyrimidine Nucleosides::Cytidinees
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Biological Phenomena::Ecological and Environmental Phenomena::Environmentes
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humanses
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Organic Chemicals::Hydrocarbons::Hydrocarbons, Cyclic::Hydrocarbons, Aromatic::Polycyclic Hydrocarbons, Aromatic::Naphthacenes::Anthracyclines::Daunorubicin::Idarubicines
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Drug Therapy::Induction Chemotherapyes
dc.subject.meshMedical Subject Headings::Health Care::Health Care Facilities, Manpower, and Services::Maintenancees
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Remission Inductiones
dc.titleAn ex vivo native environment precision medicine test shows high clinical correlation with responses to first line acute myeloid leukemia treatmentes
dc.typeconference presentation
dc.type.hasVersionVoR
dspace.entity.typePublication

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