Publication: Ciprofloxacin-Mediated Mutagenesis Is Suppressed by Subinhibitory Concentrations of Amikacin in Pseudomonas aeruginosa
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Date
2017-03
Authors
Valencia, Estela Ynes
Esposito, Fernanda
Spira, Beny
Blazquez, Jesus
Galhardo, Rodrigo S.
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Journal Title
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Volume Title
Publisher
Amer soc microbiology
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Abstract
Resistance to antibiotics is a global health problem. Activation of the SOS response, and the subsequent elevation in mutagenesis, contributes to the appearance of resistance mutations. Among currently used drugs, quinolones are the most potent inducers of the SOS response. In the present study, we show that amikacin inhibits ciprofloxacin-mediated SOS induction and mutagenesis in Pseudomonas aeruginosa.
Description
MeSH Terms
Anti-Bacterial Agents
Amikacin
Ciprofloxacin
Quinolones
Pseudomonas aeruginosa
Global Health
Pseudomonas Infections
Mutagenesis
Mutation
Amikacin
Ciprofloxacin
Quinolones
Pseudomonas aeruginosa
Global Health
Pseudomonas Infections
Mutagenesis
Mutation
DeCS Terms
Respuesta SOS en genética
Mutagénesis
Preparaciones farmacéuticas
Ciprofloxacina
Quinolonas
Antibacterianos
Amicacina
Mutación
Pseudomonas aeruginosa
Mutagénesis
Preparaciones farmacéuticas
Ciprofloxacina
Quinolonas
Antibacterianos
Amicacina
Mutación
Pseudomonas aeruginosa
CIE Terms
Keywords
Pseudomonas aeruginosa, SOS response, ciprofloxacin, recA, Sos response, Reca protein, Antibiotic-resistance, Levofloxacin, Inhibition, Combination, Chromosome, Vectors, Target, Damage
Citation
Valencia EY, Esposito F, Spira B, Blázquez J, Galhardo RS. Ciprofloxacin-Mediated Mutagenesis Is Suppressed by Subinhibitory Concentrations of Amikacin in Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2017 Feb 23;61(3):e02107-16.