RT Journal Article
T1 Ciprofloxacin-Mediated Mutagenesis Is Suppressed by Subinhibitory Concentrations of Amikacin in Pseudomonas aeruginosa
A1 Valencia, Estela Ynes
A1 Esposito, Fernanda
A1 Spira, Beny
A1 Blazquez, Jesus
A1 Galhardo, Rodrigo S.
K1 Pseudomonas aeruginosa
K1 SOS response
K1 ciprofloxacin
K1 recA
K1 Sos response
K1 Reca protein
K1 Antibiotic-resistance
K1 Levofloxacin
K1 Inhibition
K1 Combination
K1 Chromosome
K1 Vectors
K1 Target
K1 Damage
AB Resistance to antibiotics is a global health problem. Activation of the SOS response, and the subsequent elevation in mutagenesis, contributes to the appearance of resistance mutations. Among currently used drugs, quinolones are the most potent inducers of the SOS response. In the present study, we show that amikacin inhibits ciprofloxacin-mediated SOS induction and mutagenesis in Pseudomonas aeruginosa.
PB Amer soc microbiology
SN 0066-4804
YR 2017
FD 2017-03
LK http://hdl.handle.net/10668/19010
UL http://hdl.handle.net/10668/19010
LA en
NO Valencia EY, Esposito F, Spira B, Blázquez J, Galhardo RS. Ciprofloxacin-Mediated Mutagenesis Is Suppressed by Subinhibitory Concentrations of Amikacin in Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2017 Feb 23;61(3):e02107-16.
DS RISalud
RD Apr 11, 2025