Publication:
Ciprofloxacin-Mediated Mutagenesis Is Suppressed by Subinhibitory Concentrations of Amikacin in Pseudomonas aeruginosa

Simple item page
dc.contributor.authorValencia, Estela Ynes
dc.contributor.authorEsposito, Fernanda
dc.contributor.authorSpira, Beny
dc.contributor.authorBlazquez, Jesus
dc.contributor.authorGalhardo, Rodrigo S.
dc.contributor.authoraffiliation[Valencia, Estela Ynes] Univ Sao Paulo, Inst Biomed Sci, Dept Microbiol, Sao Paulo, Brazil
dc.contributor.authoraffiliation[Spira, Beny] Univ Sao Paulo, Inst Biomed Sci, Dept Microbiol, Sao Paulo, Brazil
dc.contributor.authoraffiliation[Galhardo, Rodrigo S.] Univ Sao Paulo, Inst Biomed Sci, Dept Microbiol, Sao Paulo, Brazil
dc.contributor.authoraffiliation[Esposito, Fernanda] Univ Sao Paulo, Sch Pharm, Dept Clin Anal, Sao Paulo, Brazil
dc.contributor.authoraffiliation[Blazquez, Jesus] Inst Biomed Sevilla IBIS CSIC, Seville, Spain
dc.contributor.authoraffiliation[Blazquez, Jesus] CSIC, Ctr Nacl Biotecnol, Madrid, Spain
dc.contributor.funderFundacao de Amparo a Pesquisa do Estado de Sao Paulo, Brazil (FAPESP)
dc.contributor.funderConselho Nacional de Desenvolvimento Cientifico e Tecnologico, Brazil CNPq
dc.contributor.funderpostdoctoral fellowship from CNPq
dc.contributor.funderPlan Nacional de
dc.contributor.funderInstituto de Salud Carlos III, Subdireccion General de Redes y Centros de Investigacion Cooperativa, Ministerio de Economia y Competitividad, Spanish Network for Research in Infectious Diseases
dc.contributor.funderEuropean Regional Development Fund (ERDF)
dc.date.accessioned2023-02-12T02:21:39Z
dc.date.available2023-02-12T02:21:39Z
dc.date.issued2017-03
dc.description.abstractResistance to antibiotics is a global health problem. Activation of the SOS response, and the subsequent elevation in mutagenesis, contributes to the appearance of resistance mutations. Among currently used drugs, quinolones are the most potent inducers of the SOS response. In the present study, we show that amikacin inhibits ciprofloxacin-mediated SOS induction and mutagenesis in Pseudomonas aeruginosa.
dc.description.versionSi
dc.identifier.citationValencia EY, Esposito F, Spira B, Blázquez J, Galhardo RS. Ciprofloxacin-Mediated Mutagenesis Is Suppressed by Subinhibitory Concentrations of Amikacin in Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2017 Feb 23;61(3):e02107-16.
dc.identifier.doi10.1128/AAC.02107-16
dc.identifier.essn1098-6596
dc.identifier.issn0066-4804
dc.identifier.unpaywallURLhttps://europepmc.org/articles/pmc5328548?pdf=render
dc.identifier.urihttp://hdl.handle.net/10668/19010
dc.identifier.wosID394605900063
dc.issue.number3
dc.journal.titleAntimicrobial agents and chemotherapy
dc.journal.titleabbreviationAntimicrob. agents chemother.
dc.language.isoen
dc.organizationInstituto de Biomedicina de Sevilla-IBIS
dc.page.number5
dc.provenanceRealizada la curación de contenido 1/04/2025
dc.publisherAmer soc microbiology
dc.relation.publisherversionhttps://journals.asm.org/doi/10.1128/AAC.02107-16?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
dc.rights.accessRightsRestricted Access
dc.subjectPseudomonas aeruginosa
dc.subjectSOS response
dc.subjectciprofloxacin
dc.subjectrecA
dc.subjectSos response
dc.subjectReca protein
dc.subjectAntibiotic-resistance
dc.subjectLevofloxacin
dc.subjectInhibition
dc.subjectCombination
dc.subjectChromosome
dc.subjectVectors
dc.subjectTarget
dc.subjectDamage
dc.subject.decsRespuesta SOS en genética
dc.subject.decsMutagénesis
dc.subject.decsPreparaciones farmacéuticas
dc.subject.decsCiprofloxacina
dc.subject.decsQuinolonas
dc.subject.decsAntibacterianos
dc.subject.decsAmicacina
dc.subject.decsMutación
dc.subject.decsPseudomonas aeruginosa
dc.subject.meshAnti-Bacterial Agents
dc.subject.meshAmikacin
dc.subject.meshCiprofloxacin
dc.subject.meshQuinolones
dc.subject.meshPseudomonas aeruginosa
dc.subject.meshGlobal Health
dc.subject.meshPseudomonas Infections
dc.subject.meshMutagenesis
dc.subject.meshMutation
dc.titleCiprofloxacin-Mediated Mutagenesis Is Suppressed by Subinhibitory Concentrations of Amikacin in Pseudomonas aeruginosa
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number61
dc.wostypeArticle
dspace.entity.typePublication

Files

Original bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
RISalud_Accesorestringido.pdf
Size:
93.39 KB
Format:
Adobe Portable Document Format
Download

Collections

Instituto de Investigación Biomédica de Sevilla (IBIS)

© 2023 – Repositorio Institucional de Salud de Andalucía - Fundación Pública Andaluza Progreso y Salud - Consejería de Salud y Consumo de la Junta de Andalucía