Publication: Transancestral mapping and genetic load in systemic lupus erythematosus.
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Date
2017-07-17
Authors
Langefeld, Carl D
Ainsworth, Hannah C
Cunninghame Graham, Deborah S
Kelly, Jennifer A
Comeau, Mary E
Marion, Miranda C
Howard, Timothy D
Ramos, Paula S
Croker, Jennifer A
Morris, David L
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Abstract
Systemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and ethnic disparities. We report a large transancestral association study of SLE using Immunochip genotype data from 27,574 individuals of European (EA), African (AA) and Hispanic Amerindian (HA) ancestry. We identify 58 distinct non-HLA regions in EA, 9 in AA and 16 in HA (∼50% of these regions have multiple independent associations); these include 24 novel SLE regions (P
Description
MeSH Terms
Age of Onset
American Indian or Alaska Native
Black People
Case-Control Studies
Genetic Load
HLA Antigens
Hispanic or Latino
Humans
Logistic Models
Lupus Erythematosus, Systemic
Multifactorial Inheritance
Mutagenesis, Insertional
Polymorphism, Single Nucleotide
Sequence Deletion
White People
American Indian or Alaska Native
Black People
Case-Control Studies
Genetic Load
HLA Antigens
Hispanic or Latino
Humans
Logistic Models
Lupus Erythematosus, Systemic
Multifactorial Inheritance
Mutagenesis, Insertional
Polymorphism, Single Nucleotide
Sequence Deletion
White People