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Transancestral mapping and genetic load in systemic lupus erythematosus.

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dc.contributor.authorLangefeld, Carl D
dc.contributor.authorAinsworth, Hannah C
dc.contributor.authorCunninghame Graham, Deborah S
dc.contributor.authorKelly, Jennifer A
dc.contributor.authorComeau, Mary E
dc.contributor.authorMarion, Miranda C
dc.contributor.authorHoward, Timothy D
dc.contributor.authorRamos, Paula S
dc.contributor.authorCroker, Jennifer A
dc.contributor.authorMorris, David L
dc.contributor.authorSandling, Johanna K
dc.contributor.authorAlmlöf, Jonas Carlsson
dc.contributor.authorAcevedo-Vásquez, Eduardo M
dc.contributor.authorAlarcón, Graciela S
dc.contributor.authorBabini, Alejandra M
dc.contributor.authorBaca, Vicente
dc.contributor.authorBengtsson, Anders A
dc.contributor.authorBerbotto, Guillermo A
dc.contributor.authorBijl, Marc
dc.contributor.authorBrown, Elizabeth E
dc.contributor.authorBrunner, Hermine I
dc.contributor.authorCardiel, Mario H
dc.contributor.authorCatoggio, Luis
dc.contributor.authorCervera, Ricard
dc.contributor.authorCucho-Venegas, Jorge M
dc.contributor.authorDahlqvist, Solbritt Rantapää
dc.contributor.authorD'Alfonso, Sandra
dc.contributor.authorDa Silva, Berta Martins
dc.contributor.authorde la Rúa Figueroa, Iñigo
dc.contributor.authorDoria, Andrea
dc.contributor.authorEdberg, Jeffrey C
dc.contributor.authorEndreffy, Emőke
dc.contributor.authorEsquivel-Valerio, Jorge A
dc.contributor.authorFortin, Paul R
dc.contributor.authorFreedman, Barry I
dc.contributor.authorFrostegård, Johan
dc.contributor.authorGarcía, Mercedes A
dc.contributor.authorde la Torre, Ignacio García
dc.contributor.authorGilkeson, Gary S
dc.contributor.authorGladman, Dafna D
dc.contributor.authorGunnarsson, Iva
dc.contributor.authorGuthridge, Joel M
dc.contributor.authorHuggins, Jennifer L
dc.contributor.authorJames, Judith A
dc.contributor.authorKallenberg, Cees G M
dc.contributor.authorKamen, Diane L
dc.contributor.authorKarp, David R
dc.contributor.authorKaufman, Kenneth M
dc.contributor.authorKottyan, Leah C
dc.contributor.authorKovács, László
dc.contributor.authorLaustrup, Helle
dc.contributor.authorLauwerys, Bernard R
dc.contributor.authorLi, Quan-Zhen
dc.contributor.authorMaradiaga-Ceceña, Marco A
dc.contributor.authorMartín, Javier
dc.contributor.authorMcCune, Joseph M
dc.contributor.authorMcWilliams, David R
dc.contributor.authorMerrill, Joan T
dc.contributor.authorMiranda, Pedro
dc.contributor.authorMoctezuma, José F
dc.contributor.authorNath, Swapan K
dc.contributor.authorNiewold, Timothy B
dc.contributor.authorOrozco, Lorena
dc.contributor.authorOrtego-Centeno, Norberto
dc.contributor.authorPetri, Michelle
dc.contributor.authorPineau, Christian A
dc.contributor.authorPons-Estel, Bernardo A
dc.contributor.authorPope, Janet
dc.contributor.authorRaj, Prithvi
dc.contributor.authorRamsey-Goldman, Rosalind
dc.contributor.authorReveille, John D
dc.contributor.authorRussell, Laurie P
dc.contributor.authorSabio, José M
dc.contributor.authorAguilar-Salinas, Carlos A
dc.contributor.authorScherbarth, Hugo R
dc.contributor.authorScorza, Raffaella
dc.contributor.authorSeldin, Michael F
dc.contributor.authorSjöwall, Christopher
dc.contributor.authorSvenungsson, Elisabet
dc.contributor.authorThompson, Susan D
dc.contributor.authorToloza, Sergio M A
dc.contributor.authorTruedsson, Lennart
dc.contributor.authorTusié-Luna, Teresa
dc.contributor.authorVasconcelos, Carlos
dc.contributor.authorVilá, Luis M
dc.contributor.authorWallace, Daniel J
dc.contributor.authorWeisman, Michael H
dc.contributor.authorWither, Joan E
dc.contributor.authorBhangale, Tushar
dc.contributor.authorOksenberg, Jorge R
dc.contributor.authorRioux, John D
dc.contributor.authorGregersen, Peter K
dc.contributor.authorSyvänen, Ann-Christine
dc.contributor.authorRönnblom, Lars
dc.contributor.authorCriswell, Lindsey A
dc.contributor.authorJacob, Chaim O
dc.contributor.authorSivils, Kathy L
dc.contributor.authorTsao, Betty P
dc.contributor.authorSchanberg, Laura E
dc.contributor.authorBehrens, Timothy W
dc.contributor.authorSilverman, Earl D
dc.contributor.authorAlarcón-Riquelme, Marta E
dc.contributor.authorKimberly, Robert P
dc.contributor.authorHarley, John B
dc.contributor.authorWakeland, Edward K
dc.contributor.authorGraham, Robert R
dc.contributor.authorGaffney, Patrick M
dc.contributor.authorVyse, Timothy J
dc.date.accessioned2023-01-25T09:49:07Z
dc.date.available2023-01-25T09:49:07Z
dc.date.issued2017-07-17
dc.description.abstractSystemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and ethnic disparities. We report a large transancestral association study of SLE using Immunochip genotype data from 27,574 individuals of European (EA), African (AA) and Hispanic Amerindian (HA) ancestry. We identify 58 distinct non-HLA regions in EA, 9 in AA and 16 in HA (∼50% of these regions have multiple independent associations); these include 24 novel SLE regions (P
dc.identifier.doi10.1038/ncomms16021
dc.identifier.essn2041-1723
dc.identifier.pmcPMC5520018
dc.identifier.pmid28714469
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520018/pdf
dc.identifier.unpaywallURLhttps://www.nature.com/articles/ncomms16021.pdf
dc.identifier.urihttp://hdl.handle.net/10668/11414
dc.journal.titleNature communications
dc.journal.titleabbreviationNat Commun
dc.language.isoen
dc.organizationHospital Universitario San Cecilio
dc.organizationHospital Universitario Virgen de las Nieves
dc.organizationCentro Pfizer-Universidad de Granada-Junta de Andalucía de Genómica e Investigación Oncológica-GENYO
dc.page.number16021
dc.pubmedtypeJournal Article
dc.pubmedtypeResearch Support, N.I.H., Extramural
dc.pubmedtypeResearch Support, Non-U.S. Gov't
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.meshAge of Onset
dc.subject.meshAmerican Indian or Alaska Native
dc.subject.meshBlack People
dc.subject.meshCase-Control Studies
dc.subject.meshGenetic Load
dc.subject.meshHLA Antigens
dc.subject.meshHispanic or Latino
dc.subject.meshHumans
dc.subject.meshLogistic Models
dc.subject.meshLupus Erythematosus, Systemic
dc.subject.meshMultifactorial Inheritance
dc.subject.meshMutagenesis, Insertional
dc.subject.meshPolymorphism, Single Nucleotide
dc.subject.meshSequence Deletion
dc.subject.meshWhite People
dc.titleTransancestral mapping and genetic load in systemic lupus erythematosus.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number8
dspace.entity.typePublication

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