Publication: Selenium, selenoproteins and selenometabolites in mothers and babies at the time of birth.
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2017-05-23
Authors
Santos, Cristina
García-Fuentes, Eduardo
Callejón-Leblic, Belén
García-Barrera, Tamara
Gómez-Ariza, José Luis
Rayman, Margaret P
Velasco, Inés
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Abstract
The deficiency of Se, an essential micronutrient, has been implicated in adverse pregnancy outcomes. Our study was designed to determine total serum Se, selenoproteins (extracellular glutathione peroxidase (GPx-3), selenoprotein P (SeP)), selenoalbumin (SeAlb) and selenometabolites in healthy women and their newborns at delivery. This cross-sectional study included eighty-three healthy mother-baby couples. Total Se and Se species concentrations were measured in maternal and umbilical cord sera by an in-series coupling of two-dimensional size-exclusion and affinity HPLC. Additional measurements of serum SeP concentration and of serum GPx-3 enzyme activity were carried out using ELISA. Total Se concentration was significantly higher in maternal serum than in cord serum (68·9 (sd 15·2) and 56·1 (sd 14·6) µg/l, respectively; P
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MeSH Terms
Adult
Cross-Sectional Studies
Enzyme-Linked Immunosorbent Assay
Female
Fetal Blood
Glutathione Peroxidase
Humans
Infant, Newborn
Postpartum Period
Pregnancy
Selenium
Selenoproteins
Young Adult
Cross-Sectional Studies
Enzyme-Linked Immunosorbent Assay
Female
Fetal Blood
Glutathione Peroxidase
Humans
Infant, Newborn
Postpartum Period
Pregnancy
Selenium
Selenoproteins
Young Adult
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Keywords
2D/SE-AF-HPLC two-dimensional size-exclusion and affinity HPLC, GPx-3 extracellular glutathione peroxidase, SeAlb selenoalbumin, SeMetab selenometabolites, SeP selenoprotein P, Gestation, Selenium, Selenoprotein P, Selenoproteins