RT Journal Article
T1 Selenium, selenoproteins and selenometabolites in mothers and babies at the time of birth.
A1 Santos, Cristina
A1 García-Fuentes, Eduardo
A1 Callejón-Leblic, Belén
A1 García-Barrera, Tamara
A1 Gómez-Ariza, José Luis
A1 Rayman, Margaret P
A1 Velasco, Inés
K1 2D/SE-AF-HPLC two-dimensional size-exclusion and affinity HPLC
K1 GPx-3 extracellular glutathione peroxidase
K1 SeAlb selenoalbumin
K1 SeMetab selenometabolites
K1 SeP selenoprotein P
K1 Gestation
K1 Selenium
K1 Selenoprotein P
K1 Selenoproteins
AB The deficiency of Se, an essential micronutrient, has been implicated in adverse pregnancy outcomes. Our study was designed to determine total serum Se, selenoproteins (extracellular glutathione peroxidase (GPx-3), selenoprotein P (SeP)), selenoalbumin (SeAlb) and selenometabolites in healthy women and their newborns at delivery. This cross-sectional study included eighty-three healthy mother-baby couples. Total Se and Se species concentrations were measured in maternal and umbilical cord sera by an in-series coupling of two-dimensional size-exclusion and affinity HPLC. Additional measurements of serum SeP concentration and of serum GPx-3 enzyme activity were carried out using ELISA. Total Se concentration was significantly higher in maternal serum than in cord serum (68·9 (sd 15·2) and 56·1 (sd 14·6) µg/l, respectively; P
YR 2017
FD 2017-05-23
LK http://hdl.handle.net/10668/11221
UL http://hdl.handle.net/10668/11221
LA en
DS RISalud
RD Apr 8, 2025