RT Journal Article
T1 Selenium, selenoproteins and selenometabolites in mothers and babies at the time of birth.
A1 Santos, Cristina
A1 Garcia-Fuentes, Eduardo
A1 Callejón-Leblic, Belen
A1 Garcia-Barrera, Tamara
A1 Gomez-Ariza, Jose Luis
A1 Rayman, Margaret P
A1 Velasco, Ines
K1 2D/SE-AF-HPLC two-dimensional size-exclusion and affinity HPLC
K1 GPx-3 extracellular glutathione peroxidase
K1 SeAlb selenoalbumin
K1 SeMetab selenometabolites
K1 SeP selenoprotein P
K1 Gestation
K1 Selenium
K1 Selenoprotein P
K1 Selenoproteins
K1 Área de Gestión Sanitaria Norte de Huelva
AB The deficiency of Se, an essential micronutrient, has been implicated in adverse pregnancy outcomes. Our study was designed to determine total serum Se, selenoproteins (extracellular glutathione peroxidase (GPx-3), selenoprotein P (SeP)), selenoalbumin (SeAlb) and selenometabolites in healthy women and their newborns at delivery. This cross-sectional study included eighty-three healthy mother-baby couples. Total Se and Se species concentrations were measured in maternal and umbilical cord sera by an in-series coupling of two-dimensional size-exclusion and affinity HPLC. Additional measurements of serum SeP concentration and of serum GPx-3 enzyme activity were carried out using ELISA. Total Se concentration was significantly higher in maternal serum than in cord serum (68·9 (sd 15·2) and 56·1 (sd 14·6) µg/l, respectively; P<0·01). There were significant correlations between selenoprotein and SeAlb concentrations in mothers and newborns, although they also showed significant differences in GPx-3 (11·2(SD 3·7) v.10·5(SD 3·5)µg/l; P<0·01), SeP (42·5(SD 9·5) v.28·1 (SD 7·7)µg/l; P<0·01) and SeAlb (11·6(SD 3·6) v.14·1(SD 4·3)µg/l; P<0·01) concentrations in maternal and cord sera, respectively. Serum GPx-3 activity and concentration were positively correlated in mothers (r 0·33; P=0·038) but not in newborns. GPx-3 activity in cord serum was significantly correlated with gestational age (r 0·44; P=0·009). SeAlb concentration was significantly higher in babies, whereas SeP and GPx-3 concentrations were significantly higher in mothers. The differences cannot be explained by simple diffusion; specific transfer mechanisms are probably involved. GPx-3 concentrations in mothers, at delivery, are related to maternal Se status, whereas the GPx-3 activity in cord serum depends on gestational age.
PB Cambridge University Press
YR 2017
FD 2017-05-23
LK http://hdl.handle.net/10668/11221
UL http://hdl.handle.net/10668/11221
LA en
NO Santos C, García-Fuentes E, Callejón-Leblic B, García-Barrera T, Gómez-Ariza JL, Rayman MP, et al. Selenium, selenoproteins and selenometabolites in mothers and babies at the time of birth. Br J Nutr. 2017 May;117(9):1304-1311
NO This study was undertaken with the aid of a grant from the Consejería de Salud of the Junta de Andalucía, Spain (PI-0373/ 2012) and by projects CTM2012-38720-C03-01 from the Spanish Ministry of Economy and Competitiveness (MINECO) and P12FQM-0442 from the Regional Ministry of Economy, Innovation, Science and Employment (Andalusian Government, Spain). B. C.-L. thanks the Spanish Ministry of Education, Culture and Sport for a doctoral grant.
DS RISalud
RD May 9, 2025