%0 Journal Article
%A Santos, Cristina
%A García-Fuentes, Eduardo
%A Callejón-Leblic, Belén
%A García-Barrera, Tamara
%A Gómez-Ariza, José Luis
%A Rayman, Margaret P
%A Velasco, Inés
%T Selenium, selenoproteins and selenometabolites in mothers and babies at the time of birth.
%D 2017
%U http://hdl.handle.net/10668/11221
%X The deficiency of Se, an essential micronutrient, has been implicated in adverse pregnancy outcomes. Our study was designed to determine total serum Se, selenoproteins (extracellular glutathione peroxidase (GPx-3), selenoprotein P (SeP)), selenoalbumin (SeAlb) and selenometabolites in healthy women and their newborns at delivery. This cross-sectional study included eighty-three healthy mother-baby couples. Total Se and Se species concentrations were measured in maternal and umbilical cord sera by an in-series coupling of two-dimensional size-exclusion and affinity HPLC. Additional measurements of serum SeP concentration and of serum GPx-3 enzyme activity were carried out using ELISA. Total Se concentration was significantly higher in maternal serum than in cord serum (68·9 (sd 15·2) and 56·1 (sd 14·6) µg/l, respectively; P
%K 2D/SE-AF-HPLC two-dimensional size-exclusion and affinity HPLC
%K GPx-3 extracellular glutathione peroxidase
%K SeAlb selenoalbumin
%K SeMetab selenometabolites
%K SeP selenoprotein P
%K Gestation
%K Selenium
%K Selenoprotein P
%K Selenoproteins
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