Publication: References Values of Soluble α-Klotho Serum Levels Using an Enzyme-Linked Immunosorbent Assay in Healthy Adults Aged 18-85 Years.
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Date
2022-04-25
Authors
Espuch-Oliver, Andrea
Vázquez-Lorente, Héctor
Jurado-Fasoli, Lucas
de Haro-Muñoz, Tomás
Díaz-Alberola, Irene
López-Velez, María Del Señor
de Haro-Romero, Teresa
Castillo, Manuel J
Amaro-Gahete, Francisco J
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Abstract
α-Klotho protein is a powerful predictor of the aging process and lifespan. Although lowered circulating soluble α-Klotho levels have been observed in aged non-healthy individuals, no specific reference values across a wide range of ages and sex using an enzyme-linked immunosorbent assay (ELISA) are available for larger cohorts of healthy individuals. The present analytical cross-sectional study was aimed to establish the reference values of soluble α-Klotho serum levels in healthy adults by age and sex groups. A total of 346 (59% women) healthy individuals aged from 18 to 85 years were recruited. Subjects were divided by sex and age as: (i) young (18−34.9 years), (ii) middle-aged (35−54.9 years), and (iii) senior (55−85 years) individuals. The soluble α-Klotho levels were measured in serum using ELISA. Senior adults were the age-group that presented the lowest soluble α-Klotho serum levels (p
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Keywords
ELISA, aging, references values, α-Klotho protein