%0 Journal Article
%A Espuch-Oliver, Andrea
%A Vázquez-Lorente, Héctor
%A Jurado-Fasoli, Lucas
%A de Haro-Muñoz, Tomás
%A Díaz-Alberola, Irene
%A López-Velez, María Del Señor
%A de Haro-Romero, Teresa
%A Castillo, Manuel J
%A Amaro-Gahete, Francisco J
%T References Values of Soluble α-Klotho Serum Levels Using an Enzyme-Linked Immunosorbent Assay in Healthy Adults Aged 18-85 Years.
%D 2022
%@ 2077-0383
%U http://hdl.handle.net/10668/21276
%X α-Klotho protein is a powerful predictor of the aging process and lifespan. Although lowered circulating soluble α-Klotho levels have been observed in aged non-healthy individuals, no specific reference values across a wide range of ages and sex using an enzyme-linked immunosorbent assay (ELISA) are available for larger cohorts of healthy individuals. The present analytical cross-sectional study was aimed to establish the reference values of soluble α-Klotho serum levels in healthy adults by age and sex groups. A total of 346 (59% women) healthy individuals aged from 18 to 85 years were recruited. Subjects were divided by sex and age as: (i) young (18−34.9 years), (ii) middle-aged (35−54.9 years), and (iii) senior (55−85 years) individuals. The soluble α-Klotho levels were measured in serum using ELISA. Senior adults were the age-group that presented the lowest soluble α-Klotho serum levels (p
%K ELISA
%K aging
%K references values
%K α-Klotho protein
%~