RT Journal Article
T1 References Values of Soluble α-Klotho Serum Levels Using an Enzyme-Linked Immunosorbent Assay in Healthy Adults Aged 18-85 Years.
A1 Espuch-Oliver, Andrea
A1 Vázquez-Lorente, Héctor
A1 Jurado-Fasoli, Lucas
A1 de Haro-Muñoz, Tomás
A1 Díaz-Alberola, Irene
A1 López-Velez, María Del Señor
A1 de Haro-Romero, Teresa
A1 Castillo, Manuel J
A1 Amaro-Gahete, Francisco J
K1 ELISA
K1 aging
K1 references values
K1 α-Klotho protein
AB α-Klotho protein is a powerful predictor of the aging process and lifespan. Although lowered circulating soluble α-Klotho levels have been observed in aged non-healthy individuals, no specific reference values across a wide range of ages and sex using an enzyme-linked immunosorbent assay (ELISA) are available for larger cohorts of healthy individuals. The present analytical cross-sectional study was aimed to establish the reference values of soluble α-Klotho serum levels in healthy adults by age and sex groups. A total of 346 (59% women) healthy individuals aged from 18 to 85 years were recruited. Subjects were divided by sex and age as: (i) young (18−34.9 years), (ii) middle-aged (35−54.9 years), and (iii) senior (55−85 years) individuals. The soluble α-Klotho levels were measured in serum using ELISA. Senior adults were the age-group that presented the lowest soluble α-Klotho serum levels (p
SN 2077-0383
YR 2022
FD 2022-04-25
LK http://hdl.handle.net/10668/21276
UL http://hdl.handle.net/10668/21276
LA en
DS RISalud
RD Apr 9, 2025