Publication: Influence of Peroxisome Proliferator-Activated Receptor (PPAR)-gamma Coactivator (PGC)-1 alpha gene rs8192678 polymorphism by gender on different health-related parameters in healthy young adults.
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Identifiers
Date
2022-07-04
Authors
Montes-de-Oca-Garcia, Adrian
Corral-Perez, Juan
Velazquez-Diaz, Daniel
Perez-Bey, Alejandro
Rebollo-Ramos, Maria
Marin-Galindo, Alberto
Gomez-Gallego, Félix
Calderon-Dominguez, Maria
Casals, Cristina
Ponce-Gonzalez, Jesus G
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
Frontiers Research Foundation
Abstract
This study aimed to analyze the influence of the peroxisome proliferator-activated receptor (PPAR)-gamma coactivator (PGC)-1 alpha (PPARGC1A) gene rs8192678 C>T polymorphism on different health-related parameters in male and female young adults. The PPARGC1A gene rs8192678 polymorphism was ascertained by polymerase chain reaction in 74 healthy adults (28 women; 22.72 ± 4.40 years) from Andalusia (Spain). Health-related variables included cardiometabolic risk, anthropometry and body composition, biochemical parameters, insulin sensitivity (QUICKI and HOMA-IR indexes), blood pressure (BP) at rest and after exercise, diet, basal metabolism, physical activity, maximal fat oxidation, and cardiorespiratory fitness. Our results showed differences by PPARGC1A gene rs8192678 C>T polymorphism in body mass (p = 0.002), body mass index (p = 0.024), lean body mass (p = 0.024), body fat (p = 0.032), waist circumference (p = 0.020), and BP recovery ratio (p T polymorphism on different health-related parameters in male and female young adults. The PPARGC1A gene rs8192678 polymorphism was ascertained by polymerase chain reaction in 74 healthy adults (28 women; 22.72 ± 4.40 years) from Andalusia (Spain). Health-related variables included cardiometabolic risk, anthropometry and body composition, biochemical parameters, insulin sensitivity (QUICKI and HOMA-IR indexes), blood pressure (BP) at rest and after exercise, diet, basal metabolism, physical activity, maximal fat oxidation, and cardiorespiratory fitness. Our results showed differences by PPARGC1A gene rs8192678 C>T polymorphism in body mass (p = 0.002), body mass index (p = 0.024), lean body mass (p = 0.024), body fat (p = 0.032), waist circumference (p = 0.020), and BP recovery ratio (p T polymorphism in body mass (p = 0.002), body mass index (p = 0.024), lean body mass (p = 0.024), body fat (p = 0.032), waist circumference (p = 0.020), and BP recovery ratio (p T polymorphism is associated with body composition, basal metabolism, total energy expenditure, and BP recovery, where the CC genotype confers a protective effect. Moreover, our study highlighted sexual dimorphism in the influence of PPARGC1A gene rs8192678 C>T polymorphism on the QUICKI index.
Description
MeSH Terms
Sex Characteristics
Cardiorespiratory Fitness
Body Composition
Genotype
Anthropometry
Diet
Polymerase Chain Reaction
Adipose Tissue
Cardiorespiratory Fitness
Body Composition
Genotype
Anthropometry
Diet
Polymerase Chain Reaction
Adipose Tissue
DeCS Terms
Antropometría
Capacidad cardiovascular
Caracteres sexuales
Composición corporal
Dieta
Genotipo
Reacción en cadena de la polimerasa
Tejido adiposo
Capacidad cardiovascular
Caracteres sexuales
Composición corporal
Dieta
Genotipo
Reacción en cadena de la polimerasa
Tejido adiposo
CIE Terms
Keywords
PPARGC1A, Cardiometabolic risk, Caucasian, Genetic association studies, Healthy lifestyle, Metabolism, Obesity, Physical exercise
Citation
Montes-de-Oca-García A, Corral-Pérez J, Velázquez-Díaz D, Perez-Bey A, Rebollo-Ramos M, Marín-Galindo A, et al. Influence of Peroxisome Proliferator-Activated Receptor (PPAR)-gamma Coactivator (PGC)-1 alpha gene rs8192678 polymorphism by gender on different health-related parameters in healthy young adults. Front Physiol. 2022 Jul 22;13:885185