RT Journal Article
T1 Influence of Peroxisome Proliferator-Activated Receptor (PPAR)-gamma Coactivator (PGC)-1 alpha gene rs8192678 polymorphism by gender on different health-related parameters in healthy young adults.
A1 Montes-de-Oca-Garcia, Adrian
A1 Corral-Perez, Juan
A1 Velazquez-Diaz, Daniel
A1 Perez-Bey, Alejandro
A1 Rebollo-Ramos, Maria
A1 Marin-Galindo, Alberto
A1 Gomez-Gallego, Félix
A1 Calderon-Dominguez, Maria
A1 Casals, Cristina
A1 Ponce-Gonzalez, Jesus G
K1 PPARGC1A
K1 Cardiometabolic risk
K1 Caucasian
K1 Genetic association studies
K1 Healthy lifestyle
K1 Metabolism
K1 Obesity
K1 Physical exercise
AB This study aimed to analyze the influence of the peroxisome proliferator-activated receptor (PPAR)-gamma coactivator (PGC)-1 alpha (PPARGC1A) gene rs8192678 C>T polymorphism on different health-related parameters in male and female young adults. The PPARGC1A gene rs8192678 polymorphism was ascertained by polymerase chain reaction in 74 healthy adults (28 women; 22.72 ± 4.40 years) from Andalusia (Spain). Health-related variables included cardiometabolic risk, anthropometry and body composition, biochemical parameters, insulin sensitivity (QUICKI and HOMA-IR indexes), blood pressure (BP) at rest and after exercise, diet, basal metabolism, physical activity, maximal fat oxidation, and cardiorespiratory fitness. Our results showed differences by PPARGC1A gene rs8192678 C>T polymorphism in body mass (p = 0.002), body mass index (p = 0.024), lean body mass (p = 0.024), body fat (p = 0.032), waist circumference (p = 0.020), and BP recovery ratio (p T polymorphism on different health-related parameters in male and female young adults. The PPARGC1A gene rs8192678 polymorphism was ascertained by polymerase chain reaction in 74 healthy adults (28 women; 22.72 ± 4.40 years) from Andalusia (Spain). Health-related variables included cardiometabolic risk, anthropometry and body composition, biochemical parameters, insulin sensitivity (QUICKI and HOMA-IR indexes), blood pressure (BP) at rest and after exercise, diet, basal metabolism, physical activity, maximal fat oxidation, and cardiorespiratory fitness. Our results showed differences by PPARGC1A gene rs8192678 C>T polymorphism in body mass (p = 0.002), body mass index (p = 0.024), lean body mass (p = 0.024), body fat (p = 0.032), waist circumference (p = 0.020), and BP recovery ratio (p T polymorphism in body mass (p = 0.002), body mass index (p = 0.024), lean body mass (p = 0.024), body fat (p = 0.032), waist circumference (p = 0.020), and BP recovery ratio (p T polymorphism is associated with body composition, basal metabolism, total energy expenditure, and BP recovery, where the CC genotype confers a protective effect. Moreover, our study highlighted sexual dimorphism in the influence of PPARGC1A gene rs8192678 C>T polymorphism on the QUICKI index.
PB Frontiers Research Foundation
SN 1664-042X
YR 2022
FD 2022-07-04
LK http://hdl.handle.net/10668/20716
UL http://hdl.handle.net/10668/20716
LA en
NO Montes-de-Oca-García A, Corral-Pérez J, Velázquez-Díaz D, Perez-Bey A, Rebollo-Ramos M, Marín-Galindo A, et al. Influence of Peroxisome Proliferator-Activated Receptor (PPAR)-gamma Coactivator (PGC)-1 alpha gene rs8192678 polymorphism by gender on different health-related parameters in healthy young adults. Front Physiol. 2022 Jul 22;13:885185
DS RISalud
RD Apr 8, 2025