Publication:
Short- and Long-Term Prognosis of Patients With Takotsubo Syndrome Based on Different Triggers: Importance of the Physical Nature.

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Date

2019-12-13

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Uribarri, Aitor
Núñez-Gil, Iván J
Conty, D Aritza
Vedia, Oscar
Almendro-Delia, Manuel
Duran Cambra, Albert
Martin-Garcia, Agustin C
Barrionuevo-Sánchez, Marisa
Martínez-Sellés, Manuel
Raposeiras-Roubín, Sergio

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Background Takotsubo syndrome (TTS) is an acute reversible heart condition initially believed to represent a benign pathology attributable to its self-limiting clinical course; however, little is known about its prognosis based on different triggers. This study compared short- and long-term outcomes between TTS based on different triggers, focusing on various physical triggering events. Methods and Results We analyzed patients with a definitive TTS diagnosis recruited for the Spanish National Registry on TTS (RETAKO [Registry on Takotsubo Syndrome]). Short- and long-term outcomes were compared between different groups according to triggering factors. A total of 939 patients were included. An emotional trigger was detected in 340 patients (36.2%), a physical trigger in 293 patients (31.2%), and none could be identified in 306 patients (32.6%). The main physical triggers observed were infections (30.7%), followed by surgical procedures (22.5%), physical activities (18.4%), episodes of severe hypoxia (18.4%), and neurological events (9.9%). TTS triggered by physical factors showed higher mortality in the short and long term, and within this group, patients whose physical trigger was hypoxia were those who had a worse prognosis, in addition to being triggered by physical factors, including age >70 years, diabetes mellitus, left ventricular eyection fraction 70 years, diabetes mellitus, left ventricular eyection fraction

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Aged
Aged, 80 and over
Emotions
Female
Humans
Male
Middle Aged
Prognosis
Stress, Physiological
Stress, Psychological
Takotsubo Cardiomyopathy
Time Factors

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Keywords

Takotsubo cardiomyopathy, broken heart syndrome, classification, outcome, stress, stress‐induced cardiomyopathy

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