Publication: Aquaporin-11 Contributes to TGF-β1-Induced Endoplasmic Reticulum Stress in Human Visceral Adipocytes: Role in Obesity-Associated Inflammation.
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Identifiers
Date
2020-05-31
Authors
Frühbeck, Gema
Balaguer, Inmaculada
Mendez-Gimenez, Leire
Valenti, Víctor
Becerril, Sara
Catalan, Victoria
Gomez-Ambrosi, Javier
Silva, Camilo
Salvador, Javier
Calamita, Giuseppe
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
MDPI AG
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Abstract
Aquaporin-11 (AQP11) is expressed in human adipocytes, but its functional role remains unknown. Since AQP11 is an endoplasmic reticulum (ER)-resident protein that transports water, glycerol, and hydrogen peroxide (H2O2), we hypothesized that this superaquaporin is involved in ER stress induced by lipotoxicity and inflammation in human obesity. AQP11 expression was assessed in 67 paired visceral and subcutaneous adipose tissue samples obtained from patients with morbid obesity and normal-weight individuals. We found that obesity and obesity-associated type 2 diabetes increased (p
Description
MeSH Terms
Adipocytes
Adult
Aquaporins
Cell Differentiation
Diabetes Mellitus, Type 2
Endoplasmic Reticulum Stress
Female
Gene Silencing
Humans
Inflammation
Intra-Abdominal Fat
Lipolysis
Male
Middle Aged
Models, Biological
Obesity
Transforming Growth Factor beta1
Tumor Necrosis Factor-alpha
Up-Regulation
Adult
Aquaporins
Cell Differentiation
Diabetes Mellitus, Type 2
Endoplasmic Reticulum Stress
Female
Gene Silencing
Humans
Inflammation
Intra-Abdominal Fat
Lipolysis
Male
Middle Aged
Models, Biological
Obesity
Transforming Growth Factor beta1
Tumor Necrosis Factor-alpha
Up-Regulation
DeCS Terms
Acuaporinas
Adipocitos
Diabetes Mellitus tipo 2
Diferenciación celular
Estrés del retículo endoplásmico
Factor de vecrosis tumoral alfa
Grasa intraabdominal
Inflamación
Lipólisis
Obesidad
Regulación hacia arriba
Silenciador del gen
Adipocitos
Diabetes Mellitus tipo 2
Diferenciación celular
Estrés del retículo endoplásmico
Factor de vecrosis tumoral alfa
Grasa intraabdominal
Inflamación
Lipólisis
Obesidad
Regulación hacia arriba
Silenciador del gen
CIE Terms
Keywords
aquaporins, endoplasmic reticulum stress, obesity
Citation
Frühbeck G, Balaguer I, Méndez-Giménez L, Valentí V, Becerril S, Catalán V, et al. Aquaporin-11 Contributes to TGF-β1-Induced Endoplasmic Reticulum Stress in Human Visceral Adipocytes: Role in Obesity-Associated Inflammation. Cells. 2020 Jun 4;9(6):1403.