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Aquaporin-11 Contributes to TGF-β1-Induced Endoplasmic Reticulum Stress in Human Visceral Adipocytes: Role in Obesity-Associated Inflammation.

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dc.contributor.authorFrühbeck, Gema
dc.contributor.authorBalaguer, Inmaculada
dc.contributor.authorMendez-Gimenez, Leire
dc.contributor.authorValenti, Víctor
dc.contributor.authorBecerril, Sara
dc.contributor.authorCatalan, Victoria
dc.contributor.authorGomez-Ambrosi, Javier
dc.contributor.authorSilva, Camilo
dc.contributor.authorSalvador, Javier
dc.contributor.authorCalamita, Giuseppe
dc.contributor.authorMalagon, Maria M
dc.contributor.authorRodriguez, Amaia
dc.contributor.funderFondo de Investigación Sanitaria-FEDER
dc.contributor.funderInstituto de Salud Carlos III and Ministerio de Ciencia e Innovación
dc.date.accessioned2023-02-09T09:35:28Z
dc.date.available2023-02-09T09:35:28Z
dc.date.issued2020-05-31
dc.description.abstractAquaporin-11 (AQP11) is expressed in human adipocytes, but its functional role remains unknown. Since AQP11 is an endoplasmic reticulum (ER)-resident protein that transports water, glycerol, and hydrogen peroxide (H2O2), we hypothesized that this superaquaporin is involved in ER stress induced by lipotoxicity and inflammation in human obesity. AQP11 expression was assessed in 67 paired visceral and subcutaneous adipose tissue samples obtained from patients with morbid obesity and normal-weight individuals. We found that obesity and obesity-associated type 2 diabetes increased (p
dc.description.versionSi
dc.identifier.citationFrühbeck G, Balaguer I, Méndez-Giménez L, Valentí V, Becerril S, Catalán V, et al. Aquaporin-11 Contributes to TGF-β1-Induced Endoplasmic Reticulum Stress in Human Visceral Adipocytes: Role in Obesity-Associated Inflammation. Cells. 2020 Jun 4;9(6):1403.
dc.identifier.doi10.3390/cells9061403
dc.identifier.essn2073-4409
dc.identifier.pmcPMC7349025
dc.identifier.pmid32512939
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349025/pdf
dc.identifier.unpaywallURLhttps://www.mdpi.com/2073-4409/9/6/1403/pdf?version=1591959733
dc.identifier.urihttp://hdl.handle.net/10668/15701
dc.issue.number6
dc.journal.titleCells
dc.journal.titleabbreviationCells
dc.language.isoen
dc.organizationIMIBIC
dc.page.number14
dc.provenanceRealizada la curación de contenido 06/09/2024
dc.publisherMDPI AG
dc.pubmedtypeJournal Article
dc.pubmedtypeResearch Support, Non-U.S. Gov't
dc.relation.projectIDPI16/00221
dc.relation.projectIDPI19/00785
dc.relation.projectIDI19/00990
dc.relation.projectIDBFU2016-76711-R
dc.relation.projectIDBFU2017-90578-REDT
dc.relation.publisherversionhttps://www.mdpi.com/resolver?pii=cells9061403
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectaquaporins
dc.subjectendoplasmic reticulum stress
dc.subjectobesity
dc.subject.decsAcuaporinas
dc.subject.decsAdipocitos
dc.subject.decsDiabetes Mellitus tipo 2
dc.subject.decsDiferenciación celular
dc.subject.decsEstrés del retículo endoplásmico
dc.subject.decsFactor de vecrosis tumoral alfa
dc.subject.decsGrasa intraabdominal
dc.subject.decsInflamación
dc.subject.decsLipólisis
dc.subject.decsObesidad
dc.subject.decsRegulación hacia arriba
dc.subject.decsSilenciador del gen
dc.subject.meshAdipocytes
dc.subject.meshAdult
dc.subject.meshAquaporins
dc.subject.meshCell Differentiation
dc.subject.meshDiabetes Mellitus, Type 2
dc.subject.meshEndoplasmic Reticulum Stress
dc.subject.meshFemale
dc.subject.meshGene Silencing
dc.subject.meshHumans
dc.subject.meshInflammation
dc.subject.meshIntra-Abdominal Fat
dc.subject.meshLipolysis
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshModels, Biological
dc.subject.meshObesity
dc.subject.meshTransforming Growth Factor beta1
dc.subject.meshTumor Necrosis Factor-alpha
dc.subject.meshUp-Regulation
dc.titleAquaporin-11 Contributes to TGF-β1-Induced Endoplasmic Reticulum Stress in Human Visceral Adipocytes: Role in Obesity-Associated Inflammation.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number9
dspace.entity.typePublication

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