RT Journal Article
T1 Aquaporin-11 Contributes to TGF-β1-Induced Endoplasmic Reticulum Stress in Human Visceral Adipocytes: Role in Obesity-Associated Inflammation.
A1 Frühbeck, Gema
A1 Balaguer, Inmaculada
A1 Mendez-Gimenez, Leire
A1 Valenti, Víctor
A1 Becerril, Sara
A1 Catalan, Victoria
A1 Gomez-Ambrosi, Javier
A1 Silva, Camilo
A1 Salvador, Javier
A1 Calamita, Giuseppe
A1 Malagon, Maria M
A1 Rodriguez, Amaia
K1 aquaporins
K1 endoplasmic reticulum stress
K1 obesity
AB Aquaporin-11 (AQP11) is expressed in human adipocytes, but its functional role remains unknown. Since AQP11 is an endoplasmic reticulum (ER)-resident protein that transports water, glycerol, and hydrogen peroxide (H2O2), we hypothesized that this superaquaporin is involved in ER stress induced by lipotoxicity and inflammation in human obesity. AQP11 expression was assessed in 67 paired visceral and subcutaneous adipose tissue samples obtained from patients with morbid obesity and normal-weight individuals. We found that obesity and obesity-associated type 2 diabetes increased (p
PB MDPI AG
YR 2020
FD 2020-05-31
LK http://hdl.handle.net/10668/15701
UL http://hdl.handle.net/10668/15701
LA en
NO Frühbeck G, Balaguer I, Méndez-Giménez L, Valentí V, Becerril S, Catalán V, et al. Aquaporin-11 Contributes to TGF-β1-Induced Endoplasmic Reticulum Stress in Human Visceral Adipocytes: Role in Obesity-Associated Inflammation. Cells. 2020 Jun 4;9(6):1403.
DS RISalud
RD Apr 8, 2025