Publication: Increased Expression of Musashi-1 Evidences Mesenchymal Repair in Maxillary Sinus Floor Elevation.
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Date
2018-08-16
Authors
O'Valle, Francisco
de Buitrago, Juan G
Hernández-Cortés, Pedro
Padial-Molina, Miguel
Crespo-Lora, Vicente
Cobo, Marien
Aguilar, David
Galindo-Moreno, Pablo
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Abstract
This study aimed to analyze the expression of Musashi-1 (MSI1) in maxillary native bone and grafted bone after maxillary sinus floor elevation. To do so, fifty-seven bone biopsies from 45 participants were studied. Eighteen samples were collected from native bone while 39 were obtained 6 months after maxillary sinus grafting procedures. Musashi-1 was analyzed by immunohistochemistry and RT-PCR. MSI1 was detected in osteoblasts and osteocytes in 97.4% (38/39) of grafted areas. In native bone, MSI1 was detected in only 66.6% (12/18) of the biopsies, mainly in osteocytes. Detection of MSI1 was significantly higher in osteoprogenitor mesenchymal cells of grafted biopsies (p
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MeSH Terms
Adult
Aged
Biopsy
Cell Differentiation
Female
Gene Expression Regulation
Humans
Male
Maxillary Sinus
Mesenchymal Stem Cells
Middle Aged
Nerve Tissue Proteins
Osteoblasts
Osteocytes
RNA, Messenger
RNA-Binding Proteins
Sinus Floor Augmentation
Aged
Biopsy
Cell Differentiation
Female
Gene Expression Regulation
Humans
Male
Maxillary Sinus
Mesenchymal Stem Cells
Middle Aged
Nerve Tissue Proteins
Osteoblasts
Osteocytes
RNA, Messenger
RNA-Binding Proteins
Sinus Floor Augmentation