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Solvothermal synthesis and characterization of ytterbium/iron mixed oxide nanoparticles with potential functionalities for applications as multiplatform contrast agent in medical image techniques

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Date

2022-06-17

Authors

Yeste, M. P.
Fernandez-Ponce, C.
Felix, E.
Tinoco, M.
Fernandez-Cisnal, R.
Garcia-Villar, C.
Pfaff, C.
Kriwet, J.
Natividad, E.
Cauqui, M. A.

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Elsevier
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Abstract

A solvothermal route to prepare Glutathione capped hybrid ytterbium/iron oxide nanoparticles with potential applications as multiplatform contrast agent in medical image techniques has been developed. The influence of ytterbium/iron molar ratio used as precursor, as well as the degree of the autoclave filling on the structural and morphological characteristics of the obtained nanoparticles has been extensively studied. Although all nano -particles present similar composition, with YbFeO3 being the majority phase, size and morphology of the as synthetized nanoparticles are highly influenced by the critical temperature and by the over-saturation reached during the solvothermal process. We have demonstrated that glutathione properly functionalizes the hybrid nanoparticles, increasing their colloidal stability and decreasing their cytotoxicity. Additionally, they show good imaging in magnetic resonance and X-ray computerized tomography, thereby indicating promising potential as a dual contrast agent. This work presents, for the first time, glutathione functionalized ytterbium/iron oxide nanoparticles with potential applications in Biomedicine.

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MeSH Terms

Iron
Temperature
Magnetic resonance imaging
Tomography, X-Ray computed
Nanoparticles
Magnetic resonance spectroscopy

DeCS Terms

Espectroscopía de resonancia magnética
Hierro
Imagen por resonancia magnética
Nanopartículas
Temperatura
Tomografía computarizada por rayos X

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Keywords

Ytterbium -iron nanoparticles, Functionalization, Multiplatform contrast agents, Solvothermal process, CT, MRI, Computed-tomography, Enhancement, Nanoprobe

Citation

Yeste MP, Fernández-Ponce C, Félix E, Tinoco M, Fernández-Cisnal R, García-Villar C, et al. Solvothermal synthesis and characterization of ytterbium/iron mixed oxide nanoparticles with potential functionalities for applications as multiplatform contrast agent in medical image techniques. Ceramics International [Internet]. 1 de noviembre de 2022;48(21):31191-202