RT Journal Article
T1 Solvothermal synthesis and characterization of ytterbium/iron mixed oxide nanoparticles with potential functionalities for applications as multiplatform contrast agent in medical image techniques
A1 Yeste, M. P.
A1 Fernandez-Ponce, C.
A1 Felix, E.
A1 Tinoco, M.
A1 Fernandez-Cisnal, R.
A1 Garcia-Villar, C.
A1 Pfaff, C.
A1 Kriwet, J.
A1 Natividad, E.
A1 Cauqui, M. A.
A1 Garcia-Cozar, F.
A1 Litran, R.
A1 Bomati-Miguel, O.
K1 Ytterbium -iron nanoparticles
K1 Functionalization
K1 Multiplatform contrast agents
K1 Solvothermal process
K1 CT
K1 MRI
K1 Computed-tomography
K1 Enhancement
K1 Nanoprobe
AB A solvothermal route to prepare Glutathione capped hybrid ytterbium/iron oxide nanoparticles with potential applications as multiplatform contrast agent in medical image techniques has been developed. The influence of ytterbium/iron molar ratio used as precursor, as well as the degree of the autoclave filling on the structural and morphological characteristics of the obtained nanoparticles has been extensively studied. Although all nano -particles present similar composition, with YbFeO3 being the majority phase, size and morphology of the as synthetized nanoparticles are highly influenced by the critical temperature and by the over-saturation reached during the solvothermal process. We have demonstrated that glutathione properly functionalizes the hybrid nanoparticles, increasing their colloidal stability and decreasing their cytotoxicity. Additionally, they show good imaging in magnetic resonance and X-ray computerized tomography, thereby indicating promising potential as a dual contrast agent. This work presents, for the first time, glutathione functionalized ytterbium/iron oxide nanoparticles with potential applications in Biomedicine.
PB Elsevier
SN 0272-8842
YR 2022
FD 2022-06-17
LK http://hdl.handle.net/10668/22080
UL http://hdl.handle.net/10668/22080
LA en
NO Yeste MP, Fernández-Ponce C, Félix E, Tinoco M, Fernández-Cisnal R, García-Villar C, et al. Solvothermal synthesis and characterization of ytterbium/iron mixed oxide nanoparticles with potential functionalities for applications as multiplatform contrast agent in medical image techniques. Ceramics International [Internet]. 1 de noviembre de 2022;48(21):31191-202
DS RISalud
RD Apr 7, 2025