Publication: Epigenetic clocks in relapse after a first episode of schizophrenia
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Identifiers
Date
2022-07-04
Authors
Segura, Alex-Gonzalez
Prohens, Llucia
Mezquida, Gisela
Amoretti, Silvia
Bioque, Miquel
Ribeiro, Maria
Gurriaran-Bas, Xaquin
Rementeria, Lide
Berge, Daniel
Rodriguez-Jimenez, Roberto
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
Nature portfolio
Nature Publishing Group
Nature Publishing Group
Abstract
The main objective of the present study was to investigate the association between several epigenetic clocks, covering different aspects of aging, with schizophrenia relapse evaluated over a 3-year follow-up period in a cohort of ninety-one first-episode schizophrenia patients. Genome-wide DNA methylation was profiled and four epigenetic clocks, including epigenetic clocks of chronological age, mortality and telomere length were calculated. Patients that relapsed during the follow-up showed epigenetic acceleration of the telomere length clock (p=0.030). Shorter telomere length was associated with cognitive performance (working memory, r=0.31 p=0.015; verbal fluency, r=0.28 p=0.028), but no direct effect of cognitive function or symptom severity on relapse was detected. The results of the present study suggest that epigenetic age acceleration could be involved in the clinical course of schizophrenia and could be a useful marker of relapse when measured in remission stages.
Description
MeSH Terms
DNA methylation
Memory, short-term
Schizophrenia
Aging
DNA
Epigenesis, genetic
Telomere
Disease progression
Memory, short-term
Schizophrenia
Aging
DNA
Epigenesis, genetic
Telomere
Disease progression
DeCS Terms
ADN
Envejecimiento
Epigénesis genética
Esquizofrenia
Memoria a corto plazo
Metilación de ADN
Progresión de la enfermedad
Telómero
Envejecimiento
Epigénesis genética
Esquizofrenia
Memoria a corto plazo
Metilación de ADN
Progresión de la enfermedad
Telómero
CIE Terms
Keywords
Leukocyte telomere length, Unaffected siblings, Age, Psychosis
Citation
Segura ÀG, Prohens L, Mezquida G, Amoretti S, Bioque M, Ribeiro M, et al. Epigenetic clocks in relapse after a first episode of schizophrenia. Schizophrenia (Heidelb). 2022 Jul 22;8(1):61