Publication:
Epigenetic clocks in relapse after a first episode of schizophrenia

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Date

2022-07-04

Authors

Segura, Alex-Gonzalez
Prohens, Llucia
Mezquida, Gisela
Amoretti, Silvia
Bioque, Miquel
Ribeiro, Maria
Gurriaran-Bas, Xaquin
Rementeria, Lide
Berge, Daniel
Rodriguez-Jimenez, Roberto

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Nature portfolio
Nature Publishing Group
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Abstract

The main objective of the present study was to investigate the association between several epigenetic clocks, covering different aspects of aging, with schizophrenia relapse evaluated over a 3-year follow-up period in a cohort of ninety-one first-episode schizophrenia patients. Genome-wide DNA methylation was profiled and four epigenetic clocks, including epigenetic clocks of chronological age, mortality and telomere length were calculated. Patients that relapsed during the follow-up showed epigenetic acceleration of the telomere length clock (p=0.030). Shorter telomere length was associated with cognitive performance (working memory, r=0.31 p=0.015; verbal fluency, r=0.28 p=0.028), but no direct effect of cognitive function or symptom severity on relapse was detected. The results of the present study suggest that epigenetic age acceleration could be involved in the clinical course of schizophrenia and could be a useful marker of relapse when measured in remission stages.

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MeSH Terms

DNA methylation
Memory, short-term
Schizophrenia
Aging
DNA
Epigenesis, genetic
Telomere
Disease progression

DeCS Terms

ADN
Envejecimiento
Epigénesis genética
Esquizofrenia
Memoria a corto plazo
Metilación de ADN
Progresión de la enfermedad
Telómero

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Keywords

Leukocyte telomere length, Unaffected siblings, Age, Psychosis

Citation

Segura ÀG, Prohens L, Mezquida G, Amoretti S, Bioque M, Ribeiro M, et al. Epigenetic clocks in relapse after a first episode of schizophrenia. Schizophrenia (Heidelb). 2022 Jul 22;8(1):61