RT Journal Article
T1 Epigenetic clocks in relapse after a first episode of schizophrenia
A1 Segura, Alex-Gonzalez
A1 Prohens, Llucia
A1 Mezquida, Gisela
A1 Amoretti, Silvia
A1 Bioque, Miquel
A1 Ribeiro, Maria
A1 Gurriaran-Bas, Xaquin
A1 Rementeria, Lide
A1 Berge, Daniel
A1 Rodriguez-Jimenez, Roberto
A1 Roldan, Alexandra
A1 Pomarol-Clotet, Edith
A1 Ibanez, Angela
A1 Usall, Judith
A1 Garcia-Portilla, Maria Paz
A1 Cuesta, Manuel J.
A1 Parellada, Mara
A1 Gonzalez-Pinto, Ana
A1 Berrocoso, Esther
A1 Bernardo, Miquel
A1 Mas, Sergi
K1 Leukocyte telomere length
K1 Unaffected siblings
K1 Age
K1 Psychosis
AB The main objective of the present study was to investigate the association between several epigenetic clocks, covering different aspects of aging, with schizophrenia relapse evaluated over a 3-year follow-up period in a cohort of ninety-one first-episode schizophrenia patients. Genome-wide DNA methylation was profiled and four epigenetic clocks, including epigenetic clocks of chronological age, mortality and telomere length were calculated. Patients that relapsed during the follow-up showed epigenetic acceleration of the telomere length clock (p=0.030). Shorter telomere length was associated with cognitive performance (working memory, r=0.31 p=0.015; verbal fluency, r=0.28 p=0.028), but no direct effect of cognitive function or symptom severity on relapse was detected. The results of the present study suggest that epigenetic age acceleration could be involved in the clinical course of schizophrenia and could be a useful marker of relapse when measured in remission stages.
PB Nature portfolio
PB Nature Publishing Group
YR 2022
FD 2022-07-04
LK http://hdl.handle.net/10668/19562
UL http://hdl.handle.net/10668/19562
LA en
NO Segura ÀG, Prohens L, Mezquida G, Amoretti S, Bioque M, Ribeiro M, et al. Epigenetic clocks in relapse after a first episode of schizophrenia. Schizophrenia (Heidelb). 2022 Jul 22;8(1):61
NO This study was supported by the Carlos III Healthcare Institute, the Spanish Ministry of Science, Innovation and Universities, the European Regional Development Fund (ERDF/FEDER) (PI08/0208, PI11/00325, PI14/00612); Centro de Investigación Biomé dica en Red de Salud Mental (CIBERSAM); CERCA Program; Catalan Government, the Secretariat of Universities and Research of the Department of Enterprise and Knowledge (2017SGR1562 and 2017SGR1355) and Institut de Neurociències, Universitat de Barcelona
DS RISalud
RD Apr 7, 2025